Document Detail


National Incidence and Prevalence of TSH-Secreting Pituitary Adenomas in Sweden.
MedLine Citation:
PMID:  23295463     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Context:TSH-secreting pituitary adenomas (TSHomas) are rare. Epidemiological data are scant and there are no reports on national incidence.Objective:The objective of the study was to estimate the national Swedish incidence and prevalence of TSHomas.Design:This was an observational study.Setting:The study was conducted at tertiary referral centers.Patients:The Swedish Pituitary Registry and World Health Organization International Statistical Classification of Diseases and Related Health Problems coding at all university hospitals were used to identify patients diagnosed with TSHomas 1990-2010. The identified patients' medical records were studied until the latest follow-up [median 5.0 years (range < 1-20 years)].Main Outcome Measurements:Incidence, prevalence, demographics, tumor characteristics, treatment outcome, and thyroid hormone level at diagnosis were measured.Results:The age-standardized national incidence of 28 TSHoma patients was 0.15 per 1 million inhabitants per year, with an increasing incidence over time (0.05 per 1 million per year in 1990-1994 to 0.26 per 1 million per year in 2005-2009). The national prevalence in 2010 was 2.8 per 1 million inhabitants, in which 0.85 per 1 million had active disease. Most patients (n = 22) underwent pituitary surgery, 5 had radiotherapy, and 6 had somatostatin analogues. Eighteen patients were considered cured at the latest follow-up; 25% remained uncontrolled. Subjects treated for putative primary hyperthyroidism prior to diagnosis had TSH levels more than double those with intact thyroid at diagnosis (P = .013). The median time to diagnosis was longer for women than men (4 vs < 1 year, P = .026). More women than men were treated surgically (94.1% vs 54.5%, P = .022).Conclusion:This is the first estimate of a national incidence of TSHoma. Additional epidemiological studies are needed to compare these results with other geographical areas. This study suggests an increased incidence of TSHomas, in agreement with reports on other pituitary adenomas.
Authors:
Lisa Onnestam; Katarina Berinder; Pia Burman; Per Dahlqvist; Britt Edén Engström; Jeanette Wahlberg; Helena Filipsson Nyström
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-7
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  -     ISSN:  1945-7197     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Sahlgrenska Academy (L.Ö., H.F.N.), University of Gothenburg, SE-405 30 Göteborg, Sweden; Department of Endocrinology (K.B.), Karolinska University Hospital Solna, SE-171 64 Stockholm, Sweden; Department of Endocrinology (P.B.), Skåne University Hospital, SE-214 28 Malmö-Lund, Sweden; Department of Public Health and Clinical Medicine (P.D.), Umeå University, SE-901 87 Umeå, Sweden; Department of Endocrinology (B.E.E.), Uppsala University Hospital, SE-751 85 Uppsala, Sweden; Department of Endocrinology (J.W.), University Hospital, SE-581 85 Linköping, Sweden; and Department of Endocrinology, Sahlgrenska University Hospital (H.F.N.), SE-413 45 Göteborg, Sweden.
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