| National CT colonography trial (ACRIN 6664): comparison of three full-laxative bowel preparations in more than 2500 average-risk patients. | |
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MedLine Citation:
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PMID: 21512073 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of our study was to compare the effect of three different full-laxative bowel preparations on patient compliance, residual stool and fluid, reader confidence, and polyp detection at CT colonography (CTC). SUBJECTS AND METHODS: A total of 2531 patients underwent CTC followed by colonoscopy for the American College of Radiology Imaging Network (ACRIN) National CTC Trial. Of this total, 2525 patients used one of three bowel preparations with bisacodyl tablets and stool and fluid tagging: 4 L of polyethylene glycol (PEG); 90 mL of phosphosoda; or 300 mL of magnesium citrate. Patients reported percent compliance with the bowel preparation and radiologists graded each CTC examination for the amount of residual fluid and stool on a scale from 1 (none) to 4 (nondiagnostic). Reader confidence for true-positive findings was reported on a 5-point scale: 1 (low) to 5 (high). Sensitivity and specificity for detecting polyps ≥ 6 mm and ≥ 1 cm compared with colonoscopy were calculated for each preparation. RESULTS: The most commonly prescribed preparation was phosphosoda (n = 1403) followed by PEG (n = 1020) and magnesium citrate (n = 102). Phosphosoda had the highest patient compliance (p = 0.01), least residual stool (p < 0.001), and highest reader confidence versus PEG for examinations with polyps (p = 0.06). Magnesium citrate had significantly more residual fluid compared with PEG and phosphosoda (p = 0.006). The sensitivity and specificity for detecting colon polyps ≥ 6 mm and ≥ 1 cm did not differ significantly between preparations. CONCLUSION: Polyp detection was comparable for all three preparations, although phosphosoda had significantly higher patient compliance and the least residual stool. |
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Authors:
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Amy K Hara; Mark D Kuo; Meridith Blevins; Mei-Hsiu Chen; Judy Yee; Abraham Dachman; Christine O Menias; Betina Siewert; Jugesh I Cheema; Richard G Obregon; Jeff L Fidler; Peter Zimmerman; Karen M Horton; Kevin Coakley; Revathy B Iyer; Robert A Halvorsen; Giovanna Casola; C Daniel Johnson |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: AJR. American journal of roentgenology Volume: 196 ISSN: 1546-3141 ISO Abbreviation: AJR Am J Roentgenol Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-22 Completed Date: 2011-06-28 Revised Date: 2011-11-01 |
Medline Journal Info:
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Nlm Unique ID: 7708173 Medline TA: AJR Am J Roentgenol Country: United States |
Other Details:
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Languages: eng Pagination: 1076-82 Citation Subset: AIM; IM |
Affiliation:
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Department of Diagnostic Radiology, Mayo Clinic Scottsdale, AZ 85259, USA. hara.amy@mayo.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cathartics
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diagnostic use* Citric Acid / diagnostic use* Colonic Polyps / radiography* Colonography, Computed Tomographic* Electrolytes / diagnostic use* Female Gastric Lavage Humans Male Medication Adherence Middle Aged Organometallic Compounds / diagnostic use* Phosphates / diagnostic use* Polyethylene Glycols / diagnostic use* Predictive Value of Tests United States |
| Grant Support | |
ID/Acronym/Agency:
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U01 CA79778 S2/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cathartics; 0/Electrolytes; 0/Golytely; 0/Organometallic Compounds; 0/Phosphates; 0/Polyethylene Glycols; 0/magnesium citrate; 7632-05-5/sodium phosphate; 77-92-9/Citric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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