Document Detail


Nasopharyngeal acute phase cytokines in viral upper respiratory infection: impact on acute otitis media in children.
MedLine Citation:
PMID:  19859015     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The role of acute phase cytokines generated in the nasopharynx during viral upper respiratory infection (URI) in subsequent development of acute otitis media (AOM) has not been examined.
METHODS: We studied 326 virus-positive URI episodes in 151 children aged 6-36 months. Nasopharyngeal secretions collected within 1 to 7 days of URI onset were studied for viruses by conventional and molecular techniques, and for concentrations of IL-1beta, IL-6, and TNFalpha by multiplex enzyme-linked immunosorbent assay. Children were followed up for 28 days to document AOM complication.
RESULTS: IL-1beta, IL-6, and TNFalpha concentrations correlated positively with each other (P<0.001). IL-6 and TNFalpha concentrations were higher in males than in females (P=0.01 and 0.02). IL-6 and TNFalpha concentrations were inversely correlated with age (P=0.02 and 0.05). IL-6 concentrations correlated positively with duration of fever (P=0.006) and correlated negatively with the number of days of URI symptoms (P=0.026). Furthermore, IL-6 concentrations were significantly higher during adenovirus and influenza virus URIs as compared with enterovirus and rhinovirus URIs (P<0.01). IL-1beta concentrations were higher during URI episodes with AOM than those without AOM (P<0.001).
CONCLUSIONS: We found IL-6 nasopharyngeal secretions concentrations to be higher with adenovirus and influenza infection, and in children with systemic febrile response during URI. However, IL-1beta was found to play a more important role in the development of AOM after URI. Additional studies are needed to further define the role of acute phase cytokines in virus-induced AOM.
Authors:
Janak A Patel; Sangeeta Nair; Krystal Revai; James Grady; Tasnee Chonmaitree
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  28     ISSN:  1532-0987     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-27     Completed Date:  2010-02-26     Revised Date:  2014-09-10    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1002-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Child, Preschool
Cytokines / analysis,  immunology*
Female
Humans
Infant
Male
Nasopharynx / chemistry,  immunology*
Otitis Media / epidemiology*,  etiology,  immunology
Respiratory Tract Infections / complications*,  immunology*
Virus Diseases / complications*,  immunology*
Grant Support
ID/Acronym/Agency:
M01 RR 00073/RR/NCRR NIH HHS; R01 DC 5841/DC/NIDCD NIH HHS; R01 DC005841/DC/NIDCD NIH HHS; R01 DC005841-04/DC/NIDCD NIH HHS
Chemical
Reg. No./Substance:
0/Cytokines
Comments/Corrections

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