Document Detail

Nasobiliary drainage in acute cholestatic hepatitis with pruritus.
MedLine Citation:
PMID:  18657488     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIM: Cholestatic acute viral hepatitis may have prolonged course. Pruritus is often a prominent feature and difficult to control. Sometimes it may be accompanied by severe cough. There are no reports of endoscopic nasobiliary drainage in these patients. METHODS: We prospectively evaluated the role of nasobiliary drainage in six patients with cholestatic acute viral hepatitis with intractable pruritus and accompanying severe cough in one patient in an uncontrolled study. RESULTS: There were five male and one female patient with cholestatic acute viral hepatitis with intractable pruritus. One patient also had severe cough. Nasobiliary drainage relieved pruritus in all patients and patient with cough also showed marked improvement within 24h. Nasobiliary drainage also hastened the recovery in these patients. CONCLUSIONS: Short-term nasobiliary drainage should be considered in patients with cholestatic acute viral hepatitis with intractable pruritus and cough for symptomatic relief. It may help in faster recovery in these patients. However, a larger randomized controlled study is warranted.
V Singh; A Bhalla; N Sharma; P C Dheerendra; R Agarwal; S K Mahi
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Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2008-07-25
Journal Detail:
Title:  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver     Volume:  41     ISSN:  1878-3562     ISO Abbreviation:  Dig Liver Dis     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-04     Completed Date:  2009-08-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100958385     Medline TA:  Dig Liver Dis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  442-5     Citation Subset:  IM    
Department of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
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MeSH Terms
Acute Disease
Alkaline Phosphatase / blood
Bile Acids and Salts / blood
Bilirubin / blood
Cholestasis / blood,  complications*,  therapy*
Cough / therapy,  virology
Drainage / methods*
Hepatitis, Viral, Human / blood,  complications*
Middle Aged
Prospective Studies
Pruritus / blood,  diagnosis,  therapy*,  virology*
Severity of Illness Index
Transaminases / blood
Treatment Outcome
Young Adult
Reg. No./Substance:
0/Bile Acids and Salts; 635-65-4/Bilirubin; EC 2.6.1.-/Transaminases; EC Phosphatase

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