Document Detail


Nascent aneurysm formation at the basilar terminus induced by hemodynamics.
MedLine Citation:
PMID:  18451348     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: Hemodynamic insults at arterial bifurcations are hypothesized to play a key role in intracranial aneurysm formation. This study investigates aneurysm-initiating vascular responses at the rabbit basilar terminus subsequent to common carotid artery ligation.
METHODS: Nine adult female New Zealand white rabbits were subjected to sham, unilateral, or bilateral common carotid artery ligation to produce varying degrees of compensatory basilar artery flow increase. Basilar artery flow velocity and geometry were monitored by transcranial Doppler and rotational angiography, respectively, for 12 weeks after surgery. Bifurcation tissues were harvested at 12 weeks and examined histologically. From the histological sections, we quantified the destructive structural changes at the basilar terminus and correlated them with the basilar artery flow rate increase.
RESULTS: Subsequent to common carotid artery ligation, basilar artery flow rate increased by 105% to 900% at the maximum. All common carotid artery-ligated rabbits presented nascent aneurysm formation characterized by a bulge with thinned media and absent internal elastic lamina near the basilar terminus. We defined a nascent aneurysm index based on a multiplicative combination of the local destructive remodeling lengths measured at the nascent aneurysm. The nascent aneurysm index strongly correlated with the increase in basilar artery flow rate with R(2)=0.91.
CONCLUSIONS: Without other known predisposition, flow increase alone at the basilar bifurcation can lead to a nascent aneurysm. This nascent aneurysm formation is dose-dependent on basilar artery flow increase.
Authors:
Ling Gao; Yiemeng Hoi; Daniel D Swartz; John Kolega; Adnan Siddiqui; Hui Meng
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-05-01
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  39     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-24     Completed Date:  2008-07-23     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2085-90     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Basilar Artery / pathology*
Blood Flow Velocity
Carotid Arteries / pathology
Cerebral Angiography / methods*
Disease Models, Animal
Female
Hemodynamics*
Intracranial Aneurysm / pathology*
Models, Anatomic
Rabbits
Time Factors
Grant Support
ID/Acronym/Agency:
EB002873/EB/NIBIB NIH HHS; K25 NS047242/NS/NINDS NIH HHS; K25 NS047242-05/NS/NINDS NIH HHS; NS043924/NS/NINDS NIH HHS; NS047242/NS/NINDS NIH HHS
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