Document Detail


Nasal wall compliance in vasomotor rhinitis.
MedLine Citation:
PMID:  16141379     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nasal compliance is a measure related to the blood volume in the nasal mucosa. The objective of this study was to better understand the vascular response in vasomotor rhinitis by measuring nasal cross-sectional area and nasal compliance before and after mucosal decongestion in 10 patients with vasomotor rhinitis compared with 10 healthy subjects. Nasal compliance was inferred by measuring nasal area by acoustic rhinometry at pressures ranging from atmospheric pressure to a negative pressure of -10 cmH2O. Mucosal decongestion was obtained with one puff per nostril of 0.05% oxymetazoline. At atmospheric pressure, nasal cross-sectional areas were similar in the vasomotor rhinitis group and the healthy subject group. Mucosal decongestion did not induce any decrease of nasal compliance in patients with vasomotor rhinitis in contrast with healthy subjects. Our results support the hypothesis, already proposed, of an autonomic dysfunction based on a paradoxical response of the nasal mucosa in vasomotor rhinitis. Moreover, the clearly different behavior between healthy subjects and vasomotor rhinitis subjects suggests that nasal compliance measurement may therefore represent a potential line of research to develop a diagnostic tool for vasomotor rhinitis, which remains a diagnosis of exclusion.
Authors:
Jean-François Papon; Lydia Brugel-Ribere; Redouane Fodil; Céline Croce; Christian Larger; Michel Rugina; André Coste; Daniel Isabey; Françoise Zerah-Lancner; Bruno Louis
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2005-09-01
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  100     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-16     Completed Date:  2006-02-01     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  107-11     Citation Subset:  IM    
Affiliation:
Physiopathologie et Thérapeutique Respiratoires INSERM UMR 651, Créteil, France.
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MeSH Terms
Descriptor/Qualifier:
Adult
Airway Resistance / drug effects
Elasticity / drug effects
Female
Humans
Male
Middle Aged
Nasal Decongestants / diagnostic use
Nasal Mucosa / drug effects,  physiopathology
Nose / drug effects,  physiopathology*
Oxymetazoline / diagnostic use*
Rhinitis, Vasomotor / diagnosis,  physiopathology*
Rhinometry, Acoustic / methods*
Chemical
Reg. No./Substance:
0/Nasal Decongestants; 1491-59-4/Oxymetazoline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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