Document Detail

Nasal potential difference in non-classic cystic fibrosis-long term follow up.
MedLine Citation:
PMID:  18433042     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Nasal potential difference (NPD) measurement is an electrophysiological test that assesses cystic fibrosis transmembrane conductance regulator (CFTR) activity and is a recognized diagnostic tool in CF. The aim of this study is to assess in the long term the role of NPD in patients whose diagnosis is questionable. METHODS: We performed follow up study on 70 patients with questionable CF (QCF) who were divided previously into two groups according to their NPD results: patients who likely have CF (QCF-CF) (n = 24), and those who likely do not have CF (QCF-non-CF) (n = 46). RESULTS: Sixty out of 70 patients were available for study. Sixteen patients in the QCF-CF group were being followed up at CF Centers as opposed to 1 in the QCF-non-CF group (P < 0.01). Seven patients from the QCF-CF group developed sinusitis during the follow up years compared to none from the QCF-non-CF group. During the years of the follow up, 17 QCF-non-CF patients were diagnosed with other medical conditions that could explain their previous symptoms. On repeated NPD measurement in the QCF-CF group, the results were similar to the original test. CONCLUSIONS: This study supports the diagnostic role of NPD measurement. Larger cohort studies are required for confirmation.
Ranit Jaron; Yasmin Yaakov; Joseph Rivlin; Hannah Blau; Lea Bentur; Yakov Yahav; Eitan Kerem; Haim Bibi; Elie Picard; Michael Wilschanski
Publication Detail:
Type:  Evaluation Studies; Journal Article; Validation Studies    
Journal Detail:
Title:  Pediatric pulmonology     Volume:  43     ISSN:  1099-0496     ISO Abbreviation:  Pediatr. Pulmonol.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-05     Completed Date:  2008-06-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8510590     Medline TA:  Pediatr Pulmonol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  545-9     Citation Subset:  IM    
Cystic Fibrosis Center, Hadassah University Hospital, Jerusalem, Israel.
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MeSH Terms
Cystic Fibrosis / diagnosis*,  physiopathology*
Disease Progression
Follow-Up Studies
Membrane Potentials
Nasal Mucosa / physiopathology*
Reproducibility of Results

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