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Nasal nitric oxide levels do not allow for discrimination between olfactory loss due to various etiologies.
MedLine Citation:
PMID:  23364932     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVES/HYPOTHESIS: Nasal nitric oxide (NO) and olfactory function are decreased in patients with chronic inflammatory sinonasal disease, suggesting a link between these two parameters. The aim of the study was to investigate nasal NO levels in patients with olfactory dysfunction due to different causes.
STUDY DESIGN: Prospective study in a university clinic setting (tertiary referral center).
METHODS: Posttraumatic (n = 11), idiopathic (n = 13), and sinonasal-related olfactory-impaired patients (n = 55) were compared with healthy subjects (n = 11). Nasal NO levels, olfactory testing (Sniffin' Sticks), and rhinosinusitis questionnaires (Short-Form 36, Sinonasal Outcome Test 22, Rhinosinusitis Disability Index) were obtained.
RESULTS: No significant difference in nasal NO levels were found between the different olfactory dysfunction causes. Nasal NO correlated negatively with age and positively with overall olfactory function, olfactory discrimination, and identification but not with olfactory thresholds. The more nasal symptoms prevailed in the Rhinosinusitis Disability Index, the lower the nasal NO.
CONCLUSIONS: Nasal NO levels do not allow for discrimination between olfactory loss due to various etiologies based on the present data. Nasal NO production seems to decrease with age and also seems to be associated to overall olfactory function and in particular to central nervous system tasks such as olfactory discrimination and identification but not to olfactory thresholds. These findings raise questions about the link and interaction between olfactory function and nasal NO.
Neelima Gupta; Jenny Drusch; Basile N Landis; Thomas Hummel
Publication Detail:
Type:  Journal Article     Date:  2013-01-30
Journal Detail:
Title:  The Laryngoscope     Volume:  123     ISSN:  1531-4995     ISO Abbreviation:  Laryngoscope     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  United States    
Other Details:
Languages:  eng     Pagination:  311-4     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 The American Laryngological, Rhinological, and Otological Society, Inc.
Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Dresden, Germany; Department of Otorhinolaryngology, University College of Medical Sciences and G.T.B. Hospital, Delhi, India.
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