Document Detail

Nasal nitric oxide is independent of nasal cavity volume.
MedLine Citation:
PMID:  10392235     Owner:  NLM     Status:  MEDLINE    
This study was performed to evaluate the relationship between nasal nitric oxide (NO) and changes in nasal cavity volume resulting from the topical application of xylometazoline and saline and between upright and supine posture. Nasal NO was measured using a fixed high flow technique that avoids contamination with lower airways NO. In nine healthy subjects nasal NO concentration was measured by a rapid response chemiluminescent analyzer. A tapered tube was inserted in one nostril, into which room air was insufflated to produce a constant flow of 100 mL/second; another tube was inserted into the opposite nostril for NO sampling (air exit side). Subjects were instructed to keep the vellum closed while NO was sampled through a sideport connected to the analyzer. Nasal cavity volume was measured by acoustic rhinometry from a segment of the acoustic pathway, 2 to 5 cm from the nostril. Nasal cavity volume and NO measurements were made at baseline, 15 minutes, and 60 minutes after intervention (administration of saline 0.9%, xylometazoline or posture changes on 3 consecutive days). Xylometazoline produced a significant increase in nasal cavity volume, together with a significant reduction in NO level at 15 and 60 minutes after intervention. In addition, the change from seated to supine position decreased the total nasal volume significantly, but without changes in nasal NO. No correlation was found between the magnitudes of changes in nasal NO and the changes in nasal volume. Topical application of xylomethazoline resulted in increased nasal cavity volume and reduced NO output. In contrast to previous published reports, a technique using high flow rate insufflation demonstrated an abscence of correlation between the magnitudes of changes in nasal NO and nasal cavity volume brought about by decongestant, saline, or posture.
J M Chatkin; P G Djupesland; W Qian; P McClean; H Furlott; C Gutierrez; N Zamel; J S Haight
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of rhinology     Volume:  13     ISSN:  1050-6586     ISO Abbreviation:  Am J Rhinol     Publication Date:    1999 May-Jun
Date Detail:
Created Date:  1999-09-24     Completed Date:  1999-09-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8807268     Medline TA:  Am J Rhinol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  179-84     Citation Subset:  IM    
Division of Respiratory Medicine, University of Toronto, Canada.
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MeSH Terms
Acoustic Stimulation
Imidazoles / pharmacology
Manometry / methods
Middle Aged
Nasal Cavity / anatomy & histology*,  chemistry*,  drug effects
Nasal Decongestants / pharmacology
Nitric Oxide / analysis*
Statistics as Topic
Reg. No./Substance:
0/Imidazoles; 0/Nasal Decongestants; 10102-43-9/Nitric Oxide; 526-36-3/xylometazoline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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