Document Detail


Nasal mucosal administration of chitin microparticles boosts innate immunity against influenza A virus in the local pulmonary tissue.
MedLine Citation:
PMID:  20433805     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Influenza virus infection remains a major health concern due to morbidity and mortality associated with epidemics and occasional pandemics. The absence of acquired immunity to antigenically distinct, emerging virus strains stresses the need for a generic drug that protects independent of vaccination. Here, we demonstrate that prophylactic administration of chitin microparticles (CMP) via the intranasal route significantly reduced lung viral titres and clinical signs. Pre-treatment boosted the innate immune response to subsequent infection by recruiting innate cells, such as neutrophils, and increasing inflammatory cytokines. Although an increase in virus-specific T cells was observed, the memory phase was diminished. Our data demonstrate that in the absence of prior exposure to influenza virus, CMP reduce clinical signs by boosting innate immunity.
Authors:
B J G Baaten; B Clarke; P Strong; S Hou
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-04-28
Journal Detail:
Title:  Vaccine     Volume:  28     ISSN:  1873-2518     ISO Abbreviation:  Vaccine     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-10     Completed Date:  2010-08-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406899     Medline TA:  Vaccine     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  4130-7     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Affiliation:
The Edward Jenner Institute for Vaccine Research, Compton, RG20 7NN, United Kingdom. bbaaten@sanfordburnham.org
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MeSH Terms
Descriptor/Qualifier:
Administration, Intranasal
Animals
Chitin / immunology*
Cytokines / immunology
Female
Immunity, Innate
Influenza A virus / immunology*
Influenza Vaccines / immunology
Lung / immunology*,  virology
Mice
Mice, Inbred C57BL
Neutrophils / immunology
Orthomyxoviridae Infections / immunology,  prevention & control*
T-Lymphocytes / immunology
Viral Load
Chemical
Reg. No./Substance:
0/Cytokines; 0/Influenza Vaccines; 1398-61-4/Chitin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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