Document Detail


Nasal metachromatic cells in infancy in relation to the appearance of atopic disease during the first 6 years of life.
MedLine Citation:
PMID:  9265995     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The relationship between the appearance of nasal metachromatic cells (basophils and mast cells) during the first 18 months of life and the development of respiratory and other allergic diseases up to 6 years of age was studied prospectively in 67 children. Follow-up was done at 3, 6, 9, and 18 months and 6 years. Of the 31 children who had detectable metachromatic cells in the nasal mucosa during infancy, 18 had atopic manifestations at 6 years (58%), two were probably atopic (6%), and 11 (36%) were nonatopic. The corresponding numbers for the 33 children without detectable metachromatic cells during infancy were 10 atopic (30%), two probably atopic (6%), and 21 nonatopic (64%) at 6 years (P < 0.05). Children having detectable nasal metachromatic cells at every examination were more often allergic than children with no detectable cells at any time during the 6-year follow-up period (P < 0.05). In contrast, nasal metachromatic cells were equally commonly demonstrated at 6 years in children with and without current atopic manifestations. We conclude that metachromatic cells appear at an earlier age in the nasal mucosa of atopic than nonatopic infants. The observation further supports the existence of a primary immunologic abnormality in atopic patients as related to allergic inflammatory responses. The diagnostic efficacy of this marker was too low, however, to be clinically useful as a predictor of allergy.
Authors:
M P Borres; K Irander; B Björkstén
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Allergy     Volume:  52     ISSN:  0105-4538     ISO Abbreviation:  Allergy     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-10-28     Completed Date:  1997-10-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7804028     Medline TA:  Allergy     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  770-4     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University Hospital, Faculty of Health Sciences, Linköping University, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Asthma / diagnosis,  immunology
Basophils / immunology*
Child
Dermatitis, Atopic / diagnosis,  immunology
Follow-Up Studies
Humans
Hypersensitivity, Immediate / diagnosis,  etiology,  immunology*
Infant
Infant, Newborn
Mast Cells / immunology*
Nasal Mucosa / cytology,  immunology*
Predictive Value of Tests
Prospective Studies
Rhinitis / diagnosis,  immunology
Skin Tests
Urticaria / diagnosis,  immunology
Comments/Corrections
Comment In:
Allergy. 1997 Jul;52(7):695-7   [PMID:  9265983 ]

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