Document Detail

Nasal lavage leukotrienes in infants with RSV bronchiolitis.
MedLine Citation:
PMID:  17338781     Owner:  NLM     Status:  MEDLINE    
Respiratory syncytial virus (RSV) bronchiolitis is a very common infection in infants and, after the acute phase, a number of patients develop a reactive airway disease that lasts for years. Although the pathogenesis of the lung damage after RSV bronchiolitis is still largely unknown, previous studies suggest that leukotrienes may play an active part in it. The aim of this study was to measure leukotriene levels in the nasal lavage fluid (NLF) collected in infants during RSV bronchiolitis and 1 month later. Cysteinyl leukotrienes (Cys-LTs) and leukotriene B(4) (LTB(4)) were measured in the NLF of 22 infants with their first episode of RSV bronchiolitis and 16 healthy infants. A second NLF sample was collected to measure leukotriene levels 1 month after the acute disease. NLF Cys-LT levels were significantly higher in infants with RSV bronchiolitis than in healthy controls [950 pg/ml (285.5-2155.9) vs. 110.5 pg/ml (66.5-451.3), p = 0.01], and they remained so a month after the acute infection (p = 0.02). A subanalysis showed no difference in Cys-LTs concentrations, either between bronchiolitis infants with and without a family history of atopy, or between those with and without passive exposure to cigarette smoke. No significant difference was found between the LTB(4) levels measured in the bronchiolitis cases and the control children. Cys-LTs are significantly increased in the NLF of infants with acute RSV bronchiolitis, and remain so at 1-month follow-up, suggesting a possible role of these eicosanoids in the pathogenesis of the disease.
Liviana Da Dalt; Silvia Callegaro; Silvia Carraro; Barbara Andreola; Massimo Corradi; Eugenio Baraldi
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology     Volume:  18     ISSN:  0905-6157     ISO Abbreviation:  Pediatr Allergy Immunol     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-06     Completed Date:  2007-05-01     Revised Date:  2008-05-28    
Medline Journal Info:
Nlm Unique ID:  9106718     Medline TA:  Pediatr Allergy Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  100-4     Citation Subset:  IM    
Department of Pediatrics, University of Padova, Padova, Italy.
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MeSH Terms
Bronchiolitis / metabolism*
Cysteine / analysis*
Follow-Up Studies
Leukotriene B4 / analysis*
Leukotrienes / analysis*
Nasal Lavage Fluid / chemistry*
Respiratory Syncytial Virus Infections / metabolism*
Respiratory Syncytial Virus, Human*
Reg. No./Substance:
0/Leukotrienes; 0/cysteinyl-leukotriene; 52-90-4/Cysteine; 71160-24-2/Leukotriene B4

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