Document Detail

Nasal indices of eosinophilic and exudative inflammation in bakery-workers.
MedLine Citation:
PMID:  17204034     Owner:  NLM     Status:  MEDLINE    
AIMS: Rhinitis symptoms frequently occur in bakery-workers. Yet, little is known about the pathophysiology of this condition. The objective of the present study was to examine nasal indices of inflammation in relation to occupational dust exposure, occupational rhinitis according to defined criteria, rhinitis symptoms associated to the workplace, and occupational sensitization in bakery-workers. METHODS: Bakery-workers (n = 197) were subjected to interviews, questionnaires, workplace dust measurements, allergy tests, and nasal lavages with and without histamine. alpha(2)-Macroglobulin and eosinophil cationic protein (ECP) were measured in saline lavages as indices of plasma exudation and eosinophilic activity, respectively. Histamine lavages were employed to explore the nasal exudative responsiveness. RESULTS: alpha(2)-Macroglobulin and ECP increased significantly by increased workplace dust exposure (P< or =0.035). Furthermore, the exudative responsiveness to histamine increased significantly by such exposure (P< or =0.016). Similar patterns were seen in workers with occupational rhinitis and in subjects with rhinitis symptoms associated to the workplace, but not in workers with occupational sensitization. CONCLUSIONS: We conclude that occupational dust exposure in bakery-workers is associated with nasal eosinophilic exudative inflammation. In contrast, occupational sensitization is not a discriminating factor with regard to indices of eosinophilic, exudative inflammation in the present material.
Torgeir Storaas; Laila Ardal; Thien Van Do; Erik Florvaag; Sverre K Steinsvåg; Agot Irgens; Tor B Aasen; Lennart Greiff
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical physiology and functional imaging     Volume:  27     ISSN:  1475-0961     ISO Abbreviation:  Clin Physiol Funct Imaging     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-05     Completed Date:  2007-03-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137604     Medline TA:  Clin Physiol Funct Imaging     Country:  England    
Other Details:
Languages:  eng     Pagination:  23-9     Citation Subset:  IM    
Department of Otolaryngology/Head & Neck Surgery, Haukeland University Hospital, Bergen, Norway.
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MeSH Terms
Bronchiolitis Obliterans / epidemiology*,  immunology
Dust / analysis*
Eosinophilia / epidemiology*,  immunology
Food-Processing Industry / statistics & numerical data*
Middle Aged
Norway / epidemiology
Nose / immunology
Occupational Diseases / epidemiology*,  immunology
Occupational Exposure / analysis*
Rhinitis / epidemiology*,  immunology
Risk Assessment / methods
Severity of Illness Index
Reg. No./Substance:

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