Document Detail

Nasal fractional exhaled nitric oxide analysis with a novel hand-held device.
MedLine Citation:
PMID:  18444488     Owner:  NLM     Status:  MEDLINE    
AIM: To assess the performance of a novel hand-held nitric oxide (NO) analyzer in the measurement of nasal fractional exhaled NO (FE(NO)). METHODS: In ten healthy subjects (controls) and ten patients with chronic rhinosinusitis (CRS), oral and nasal FENO were obtained with the NIOX MINO Airway Inflammation Monitor (Aerocrine AB, Solna, Sweden) on two consecutive days, complying with current standards. RESULTS: Intraclass correlation coefficient (ICC) of oral FENO was 0.91 and of nasal FE(NO) 0.79. In controls, mean (+/- SD) nasal FENO (40.3 +/- 23.6 ppb) was higher than oral FENO (15.6 +/- 2.7 ppb; p = 0.005). In CRS patients, mean oral FENO (23.9 +/- 12.2 ppb) was higher than in controls (15.6 +/- 2.7 ppb; p = 0.01). CRS patients with nasal polyps had lower nasal FE(NO) levels (19.7 +/- 5.9) than healthy controls (40.3 +/- 23.6 ppb; p = 0.01). CONCLUSIONS: The novel hand-held NO analyzer was found suitable for nasal FE(NO) measurements. It may be useful in differentiating hyperplasic eosinophil rhinosinusitis from chronic unspecific rhinosinusitis. Moreover, nasal FE(NO) may be used to monitor the clinical course of CRS with polyps.
Michael Weschta; Tom Deutschle; Herbert Riechelmann
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Rhinology     Volume:  46     ISSN:  0300-0729     ISO Abbreviation:  Rhinology     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-04-30     Completed Date:  2008-07-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0347242     Medline TA:  Rhinology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  23-7     Citation Subset:  IM    
Department of Otorhinolaryngology & Head and Neck Surgery, University Hospital of Ulm, Germany.
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MeSH Terms
Breath Tests / instrumentation*,  methods
Chronic Disease
Equipment Design / trends
Nitric Oxide / analysis*,  diagnostic use
Pilot Projects
Reproducibility of Results
Rhinitis / diagnosis
Sensitivity and Specificity
Sinusitis / diagnosis
Reg. No./Substance:
10102-43-9/Nitric Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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