Document Detail

Nasal epithelium potential difference at high altitude (4,559 m): evidence for secretion.
MedLine Citation:
PMID:  12522027     Owner:  NLM     Status:  MEDLINE    
Hypoxia inhibits activity and expression of ion transport proteins of cultured lung alveolar epithelial cells. Here we tested, whether in vivo hypoxia at high altitude (4,559 m) also inhibits lung ion transport. Transepithelial nasal potentials (NP) were determined as a surrogate measure of lung ion transport activity before and during the stay at altitude. In normoxia, total NP was approximately 20% higher in control subjects than in susceptibles to high-altitude pulmonary edema, but there was no difference between groups in amiloride-inhibitable NPs. At high altitude total NP increased 250% in both groups, whereas amiloride-sensitive NP decreased in control subjects only (-80%), and the chloride ion (Cl-)-sensitive portion of NP almost doubled. Because many mountaineers suffer from nasal dryness at high altitude, a control study was performed in normobaric hypoxia (12% oxygen, 6 hours) at a controlled humidity of 50%. In this study, no change in total NP or its amiloride- and Cl-sensitive portions was observed. The increased Cl- secretion at high altitude but no such change in normobaric hypoxia suggests that nasal dryness may stimulate local active Cl- and fluid secretion in the upper respiratory tract. It is therefore uncertain whether similar changes also occur at the alveolar epithelium.
Heimo Mairbäurl; Jörn Weymann; Andreas Möhrlein; Erik R Swenson; Marco Maggiorini; J Simon R Gibbs; Peter Bärtsch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-01-09
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  167     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-07     Completed Date:  2003-04-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  862-7     Citation Subset:  AIM; IM    
Division of Sports Medicine, Department of Medicine, University of Heidelberg, Luisenstrasse 5, Geb. 4100, 69115 Heidelberg, Germany.
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MeSH Terms
Altitude Sickness / diagnosis,  etiology,  metabolism*
Amiloride / pharmacology
Blood Gas Analysis
Case-Control Studies
Chlorides / metabolism*
Disease Susceptibility / diagnosis,  etiology,  metabolism*
Diuretics / pharmacology
Epinephrine / blood
Ion Transport
Membrane Potentials
Middle Aged
Nasal Mucosa / drug effects,  metabolism*,  secretion*
Norepinephrine / blood
Pulmonary Edema / diagnosis,  etiology,  metabolism*
Sodium / metabolism*
Reg. No./Substance:
0/Chlorides; 0/Diuretics; 2609-46-3/Amiloride; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 7440-23-5/Sodium

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