Document Detail

Nasal eosinophilia as a marker for allergic rhinitis: A controlled study of 50 patients.
MedLine Citation:
PMID:  22430337     Owner:  NLM     Status:  In-Data-Review    
Eosinophils are the principal effector cells involved in the pathogenesis of allergic inflammation. We conducted a study to investigate the validity of the nasal smear examination for detecting eosinophilia in patients with allergic rhinitis. Our study group was made up of 50 patients with allergic rhinitis and 50 age- and sex-matched controls without allergic rhinitis. Smears were obtained from nasal secretions in both groups and then fixed, stained, and studied under light microscopy. Statistical analysis revealed that the odds ratio for eosinophilia positivity in nasal smears in the rhinitis group was 25.61 with a 95% confidence interval of 8 to 78. The sensitivity, specificity, positive predictive value, and negative predictive value of this test were 74, 90, 88, and 77%, respectively. We conclude that the nasal eosinophilia test is highly specific and moderately sensitive in diagnosing allergic rhinitis, and that it therefore can be used as an easy, noninvasive, and inexpensive procedure for screening patients and for conducting epidemiologic studies of this disorder.
Akefeh Ahmadiafshar; Daryoosh Taghiloo; Abdolreza Esmailzadeh; Behnaz Falakaflaki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ear, nose, & throat journal     Volume:  91     ISSN:  1942-7522     ISO Abbreviation:  Ear Nose Throat J     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7701817     Medline TA:  Ear Nose Throat J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  122-4     Citation Subset:  IM    
Department of Allergy, Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran.
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