Document Detail

Nasal continuous positive airway pressure. Improvement in arterial oxygenation in hyaline membrane disease.
MedLine Citation:
PMID:  8164     Owner:  NLM     Status:  MEDLINE    
Continuous positive airway pressure (CPAP) was employed using nasal prongs in 30 neonates with hyaline membrane disease (HMD). There was a significant improvement in mean PaO2 (from 47 to 80 mmHg;p less than 0.001) with no significant change in PaCO2 or pH within a mean 36 min of therapy. Use of the technique allowed reduction of FiO2 to less than 0.60 in less than 20 h in 18 infants. Infants treated within 24 h of birth had significantly greater improvements in PaO2. Complications were infrequent and only 3 of 30 babies developed a pneumothorax while on nasal CPAP. Only 1 of the 23 survivors required mechanical ventilation in addition to nasal CPAP.
H Harris; S Wilson; Y Brans; D Wirtschafter; G Cassady
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biology of the neonate     Volume:  29     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1976  
Date Detail:
Created Date:  1976-10-20     Completed Date:  1976-10-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  231-7     Citation Subset:  IM    
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MeSH Terms
Carbon Dioxide / blood
Hyaline Membrane Disease / therapy*
Hydrogen-Ion Concentration
Infant, Newborn
Oxygen / blood*
Partial Pressure
Positive-Pressure Respiration* / adverse effects,  instrumentation
Time Factors
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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