Document Detail

Nasal continuous positive airway pressure decreases respiratory muscles overload in young infants with severe acute viral bronchiolitis.
MedLine Citation:
PMID:  18607564     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the efficacy of nasal continuous positive airway pressure (nCPAP) on respiratory distress symptoms and respiratory effort in young infants with acute respiratory syncytial virus bronchiolitis. DESIGN: Prospective study. SETTING: The paediatric intensive care unit of a university hospital. PATIENTS: Twelve infants less than 3 months of age, with severe respiratory distress. INTERVENTIONS: Respiratory distress was quantified with a specific scoring system. Oesophageal pressure (Pes) was measured during spontaneous ventilation before and after nCPAP, delivered through an infant-adapted ventilator. Simultaneous recording of gastric pressure (Pgas) was performed in the five oldest patients. MEASUREMENTS AND RESULTS: The respiratory distress score decreased after nCPAP, particularly accessory muscles' use and expiratory wheezing. The breathing pattern was modified, with shorter inspiratory and longer expiratory time. Pes swings and PTPes(insp), two indices of inspiratory effort, were reduced by 54 (+/-4)% and 59 (+/-5)%. PTPgas(exp), an indicator of expiratory muscles activity, was completely abolished. A significant correlation was observed between the respiratory distress score and Pes swings at baseline and after nCPAP. CONCLUSIONS: In young infants with severe acute respiratory syncytial virus bronchiolitis, nCPAP rapidly unloads respiratory muscles and improves respiratory distress symptoms.
Gilles Cambonie; Christophe Milési; Samir Jaber; Francis Amsallem; Eric Barbotte; Jean-Charles Picaud; Stefan Matecki
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2008-07-08
Journal Detail:
Title:  Intensive care medicine     Volume:  34     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-29     Completed Date:  2009-02-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1865-72     Citation Subset:  IM    
Pediatric Intensive Care Unit, CHU Montpellier, 34000 Montpellier, France.
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MeSH Terms
Bronchiolitis, Viral / therapy*
Continuous Positive Airway Pressure*
Infant, Newborn
Prospective Studies
Respiratory Muscles / physiology
Respiratory Syncytial Virus Infections / therapy*
Severity of Illness Index
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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