| Nasal conditioning in perennial allergic rhinitis after nasal allergen challenge. | |
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MedLine Citation:
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PMID: 15248856 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Antigen challenge in seasonal allergic rhinitis is considered to be associated with an increased ability of the nose to condition inspired air. In contrast, little is known about air conditioning after antigen challenge in perennial allergic rhinitis (PAR). OBJECTIVE: The aims of this study were to investigate whether antigen challenge in PAR changes nasal air conditioning and to assess the relationship between nasal conditioning and nasal patency and geometry. METHODS: Nineteen subjects with PAR were enrolled into this study. Measurement of nasal conditioning, active anterior rhinomanometry (AAR), acoustic rhinometry (AR), and clinical symptom evaluation were performed before and after nasal allergen challenge with allergen extracts from house dust mites. RESULTS: Ten and 20 min after nasal allergen challenge, the total water content of the air measured in the nasopharynx and the water gradient across the nose were significantly higher in the nasal cavity in which the allergen extract was sprayed. The temperature on both sides of the nose increased non-significantly after nasal allergen challenge. No correlation to data obtained by AAR, AR, and clinical symptom evaluation after nasal allergen challenge was found. CONCLUSION: We suggest that an increase in mucosal humidity due to the allergic provocation might be responsible for the increase in nasal conditioning capacity because no correlation to changes in nasal perimeter and patency was found. |
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Authors:
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A Rozsasi; R Leiacker; T Keck |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology Volume: 34 ISSN: 0954-7894 ISO Abbreviation: Clin. Exp. Allergy Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2004-07-13 Completed Date: 2004-11-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8906443 Medline TA: Clin Exp Allergy Country: England |
Other Details:
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Languages: eng Pagination: 1099-104 Citation Subset: IM |
Affiliation:
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Department of Otorhinolaryngology, University of Ulm, Ulm, Germany. ajnirozsasi@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological Adult Antigens, Dermatophagoides / diagnostic use* Female Humans Humidity Male Middle Aged Nasal Mucosa / immunology* Nasal Provocation Tests Rhinitis, Allergic, Perennial / immunology* Rhinomanometry Rhinometry, Acoustic |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Dermatophagoides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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