Document Detail

Nasal cocaine abuse causing an aggressive midline intranasal and pharyngeal destructive process mimicking midline reticulosis and limited Wegener's granulomatosis.
MedLine Citation:
PMID:  2388208     Owner:  NLM     Status:  MEDLINE    
We describe a 36-year-old white man with an aggressive, midline intranasal and naso and oropharyngeal destructive process temporally associated with heavy (3 g/week) abuse of nasal cocaine. Necrosis and atrophy of the inferior and middle nasal turbinates bilaterally, prominent naso and oropharyngeal ulcers, and nasal septal perforation were observed clinically. Biopsies of a necrotic posterior oropharyngeal ulcer revealed focal areas of chronic inflammation and necrosis, but there was no evidence of vasculitis or granuloma formation. Serum was negative for antineutrophil cytoplasmic antibody. The oropharyngeal ulcer improved with abstinence from cocaine. Nasal septal perforation is a well recognized complication of nasal cocaine insufflation. Our case illustrates that a more aggressive midline intranasal and intrapharyngeal destructive process mimicking limited Wegener's granulomatosis and midline reticulosis can be associated with nasal cocaine abuse.
R B Daggett; P Haghighi; R A Terkeltaub
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  17     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-09-27     Completed Date:  1990-09-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  838-40     Citation Subset:  IM    
Rheumatology Division, University of California, San Diego.
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MeSH Terms
Administration, Intranasal
Diagnosis, Differential
Lymphatic Diseases / diagnosis*,  pathology
Nose Diseases / diagnosis*,  etiology,  pathology
Pharyngeal Diseases / diagnosis*,  etiology,  pathology
Substance-Related Disorders / complications*
Wegener Granulomatosis / diagnosis*,  pathology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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