Document Detail

Nasal bilevel vs. continuous positive airway pressure in preterm infants.
MedLine Citation:
PMID:  16155882     Owner:  NLM     Status:  MEDLINE    
Our aim was to compare the effects of nasal bilevel positive airway pressure (N-BiPAP) and nasal continuous positive airway pressure (N-CPAP) on gas exchange in preterm babies. Twenty preterm infants (mean gestational age, 26.3 weeks; mean weight at study, 1,033 g) were evaluated. Patients received two repeated cycles of N-CPAP alternated with N-BiPAP, for a total of four alternated phases, each phase lasting 1 hr. Transcutaneous PO2 (TcPO2), transcutaneous PCO2 (tcPCO2), pulsoximetry, and respiratory rate were recorded every 15 min. Arterial blood gases and acid-base balance were measured at the beginning of the first study period on baseline CPAP and at the end of the last study period on bilevel positive airway pressure. During the two N-BiPAP phases, a statistically significant (P < 0.001) increase of peripheral oxygen saturation and tcPO2, and a significant (P < 0.001) reduction of tcPCO2 and respiratory rate, were noted as compared to the two N-CPAP periods. In addition, a significant improvement of PO2 (P < 0.003) and a reduction of PCO2 were noted at the end of the test (P < 0.02). In conclusion, N-BiPAP, as compared to N-CPAP, improved gas exchange in preterm infants.
Claudio Migliori; Mario Motta; Agnese Angeli; Gaetano Chirico
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Pediatric pulmonology     Volume:  40     ISSN:  8755-6863     ISO Abbreviation:  Pediatr. Pulmonol.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-03     Completed Date:  2006-03-16     Revised Date:  2006-03-28    
Medline Journal Info:
Nlm Unique ID:  8510590     Medline TA:  Pediatr Pulmonol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  426-30     Citation Subset:  IM    
Copyright Information:
(c) 2005 Wiley-Liss, Inc.
Division of Neonatology and Neonatal Intensive Care Unit, Spedali Civili, Brescia, Italy.
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MeSH Terms
Blood Gas Analysis
Carbon Dioxide / blood
Continuous Positive Airway Pressure*
Cross-Over Studies
Infant, Newborn
Infant, Premature
Oxygen / blood
Positive-Pressure Respiration / methods*
Pulmonary Gas Exchange
Respiratory Distress Syndrome, Newborn / therapy*
Respiratory Mechanics
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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