| Nasal absorption and local tissue reaction of insulin nanocomplexes of trimethyl chitosan derivatives in rats. | |
| | |
MedLine Citation:
|
PMID: 20609059 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: The objective of this work was to explore the potential and safety of trimethyl chitosan (TMC) and PEGylated TMC for improved absorption of insulin after nasal administration. METHODS: The nasal absorption of insulin nanocomplexes of TMC or PEGylated TMC was evaluated in anaesthetized rats. Concomitantly, the histopathological effects of these nanocomplexes on rat nasal mucosa were studied using a perfusion fixation technique. KEY FINDINGS: All insulin nanocomplexes containing TMC or PEGylated TMC showed a 34-47% reduction in the blood glucose concentration, when the insulin absorption through the rat nasal mucosa was measured indirectly. In addition, the relative pharmacodynamic bioavailability (F(dyn)) of the formulations was found to be dependent upon the charge ratio of insulin and polymer, regardless of polymer structure. The F(dyn) apparently decreased with increasing charge ratio of insulin : polymer. Although acute alterations in nasal morphology by the formulations were affected by the charge ratio of insulin and polymer, the formulation of insulin/PEGylated TMC nanocomplexes was shown to be less toxic to the nasal epithelial membrane than insulin/TMC nanocomplexes. CONCLUSIONS: PEGylated TMC nanocomplexes were a suitable absorption enhancer for nasal delivery of insulin. |
| | |
Authors:
|
Anchalee Jintapattanakit; Penchom Peungvicha; Achariya Sailasuta; Thomas Kissel; Varaporn Buraphacheep Junyaprasert |
Related Documents
:
|
7760229 - Jejunal mucosal function of the isolated bowel segment created by omentoenteropexy in d... 10737549 - Non-starch polysaccharides extracted from seaweed can modulate intestinal absorption of... 18540249 - Short-term high dietary fructose intake had no effects on insulin sensitivity and secre... 19481619 - The effect of complexation hydrogels on insulin transport in intestinal epithelial cell... 15083319 - Green tea supplementation ameliorates insulin resistance and increases glucose transpor... 15288339 - Nasal insulin delivery in the chitosan solution: in vitro and in vivo studies. 4443809 - Neuropathology of the oesophagus in diabetes mellitus. 8082829 - Involvement of endocytosis in catabolite inactivation of the k+ and glucose transport s... 21245879 - Effects of oral ingestion of sucralose on gut hormone response and appetite in healthy ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Journal of pharmacy and pharmacology Volume: 62 ISSN: 2042-7158 ISO Abbreviation: J. Pharm. Pharmacol. Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-07-08 Completed Date: 2011-01-31 Revised Date: 2011-09-13 |
Medline Journal Info:
|
Nlm Unique ID: 0376363 Medline TA: J Pharm Pharmacol Country: England |
Other Details:
|
Languages: eng Pagination: 583-91 Citation Subset: IM |
Affiliation:
|
Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Absorption Administration, Intranasal Animals Biological Availability Biophysical Processes Blood Glucose / metabolism* Chemistry, Pharmaceutical / methods Chitosan / administration & dosage, adverse effects, pharmacokinetics* Drug Carriers / administration & dosage, pharmacokinetics, toxicity Hypoglycemic Agents / administration & dosage, pharmacokinetics*, pharmacology Insulin / administration & dosage, pharmacokinetics*, pharmacology Male Nanoparticles Nasal Mucosa / drug effects*, pathology Polyethylene Glycols / administration & dosage, adverse effects, pharmacokinetics* Polymers / chemistry Rats Rats, Wistar Technology, Pharmaceutical / methods* |
| Chemical | |
Reg. No./Substance:
|
0/Blood Glucose; 0/Drug Carriers; 0/Hypoglycemic Agents; 0/Polyethylene Glycols; 0/Polymers; 11061-68-0/Insulin; 9012-76-4/Chitosan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Molecularly imprinted polymers as drug delivery systems for the sustained release of glycyrrhizic ac...
Next Document: Inhibition of human liver microsomal CYP by nateglinide.