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Nasal Intermittent Positive Pressure Ventilation versus Nasal Continuous Positive Airway Pressure in Neonates: A Systematic Review and Meta-analysis.
MedLine Citation:
PMID:  23255684     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To compare the efficacy and safety of nasal intermittent positive pressure ventilation (NIPPV) and nasal continuous positive airway pressure (nCPAP) in neonates. METHODS: Study design: Systematic review and meta-analysis. Standard search strategy for the Cochrane Neonatal Review Group was performed. The participants were both preterm and term infants suffering from neonatal respiratory distress syndrome or experiencing apnea of prematurity. RESULTS: 14 eligible andomized controlled trials involving 1052 newborn infants were included. The study quality and evidence validity was defined as moderate. As compared with nCPAP, NIPPV significantly reduced the incidence of endotracheal ventilation (OR=0.44, 95% CI:0.31?0.63), increased the successful rate of extubation (OR=0.15, 95% CI:0.08?0.31), and had a better outcome indicated by decreased death and/or bronchopulmonary dysplasia (OR=0.57, 95%CI:0.37?0.88). Moreover, NIPPV decreased the number of apneic episodes of prematurity (WMD=-0.48, 95% CI:-0.58 ? - 0.37), marginally decreased the incidence of bronchopulmonary dysplasia(OR=0.63, 95% CI:0.39?1.00). No specific side effects were reported associated with NIPPV. CONCLUSIONS: NIPPV could be used to reduce endotracheal ventilation, increase successful extubation, decrease the rate of apnea of prematurity, and have better outcome indicated by fewer death and/or bronchopulmonary dysplasia in preterm and term newborn infants.
Shifang Tang; Jinning Zhao; Jie Shen; Zhangxue Hu; Yuan Shi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-05
Journal Detail:
Title:  Indian pediatrics     Volume:  -     ISSN:  0974-7559     ISO Abbreviation:  Indian Pediatr     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-12-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985062R     Medline TA:  Indian Pediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Pediatrics, Daping Hospital, Institute of Surgery Research, Third Military Medical University, Chongqing 400042, China. Correspondence to: Dr Yuan Shi, Director and Professor, Department of Pediatrics, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
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