| Narrative review: the role of leptin in human physiology: emerging clinical applications. | |
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MedLine Citation:
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PMID: 20083828 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Leptin is a hormone secreted by adipose tissue in direct proportion to amount of body fat. The circulating leptin levels serve as a gauge of energy stores, thereby directing the regulation of energy homeostasis, neuroendocrine function, and metabolism. Persons with congenital deficiency are obese, and treatment with leptin results in dramatic weight loss through decreased food intake and possible increased energy expenditure. However, most obese persons are resistant to the weight-reducing effects of leptin. Recent studies suggest that leptin is physiologically more important as an indicator of energy deficiency, rather than energy excess, and may mediate adaptation by driving increased food intake and directing neuroendocrine function to converse energy, such as inducing hypothalamic hypogonadism to prevent fertilization. Current studies investigate the role of leptin in weight-loss management because persons who have recently lost weight have relative leptin deficiency that may drive them to regain weight. Leptin deficiency is also evident in patients with diet- or exercise-induced hypothalamic amenorrhea and lipoatrophy. Replacement of leptin in physiologic doses restores ovulatory menstruation in women with hypothalamic amenorrhea and improves metabolic dysfunction in patients with lipoatrophy, including lipoatrophy associated with HIV or highly active antiretroviral therapy. The applications of leptin continue to grow and will hopefully soon be used therapeutically. |
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Authors:
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Theodore Kelesidis; Iosif Kelesidis; Sharon Chou; Christos S Mantzoros |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Annals of internal medicine Volume: 152 ISSN: 1539-3704 ISO Abbreviation: Ann. Intern. Med. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-19 Completed Date: 2010-01-26 Revised Date: 2011-07-20 |
Medline Journal Info:
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Nlm Unique ID: 0372351 Medline TA: Ann Intern Med Country: United States |
Other Details:
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Languages: eng Pagination: 93-100 Citation Subset: AIM; IM |
Affiliation:
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Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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metabolism,
pathology Amenorrhea / etiology, physiopathology Animals Atrophy / etiology, physiopathology Energy Metabolism / physiology Female Humans Insulin Resistance Leptin / deficiency*, physiology*, therapeutic use Male Metabolic Syndrome X / physiopathology Neurosecretory Systems / physiology Obesity / drug therapy, metabolism, physiopathology Recombinant Proteins / therapeutic use Weight Loss / physiology |
| Grant Support | |
ID/Acronym/Agency:
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DK 79929/DK/NIDDK NIH HHS; DK 81913/DK/NIDDK NIH HHS; DK58785/DK/NIDDK NIH HHS; K24 DK081913-02/DK/NIDDK NIH HHS; R01 DK058785-02/DK/NIDDK NIH HHS; R01 DK079929-02/DK/NIDDK NIH HHS; R01 DK079929-04/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Leptin; 0/Recombinant Proteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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