Document Detail

Percutaneous heart valve replacement for aortic stenosis: state of the evidence.
MedLine Citation:
PMID:  20679543     Owner:  NLM     Status:  MEDLINE    
Surgical aortic valve replacement (SAVR) is the only treatment known to improve symptoms and survival in patients with severe, symptomatic aortic stenosis. Perioperative mortality, however, is high among many patients for whom SAVR may be indicated. Percutaneous heart valve replacement (PHVR) is an emerging, catheter-based technology that allows for implantation of a prosthetic valve without open heart surgery. This review describes the available literature on PHVR for aortic stenosis, which comprised 84 published reports representing 76 distinct studies and 2375 unique patients. Successful implantation was achieved in 94% of patients; 30-day survival was 89%. Differences between patients undergoing PHVR and those typically selected for SAVR make full interpretation of these results difficult. A large, multicenter, randomized, controlled trial comparing PHVR with SAVR or medical management was recently completed, with initial results expected in September 2010. Pending publication of findings from that trial, the available evidence is inadequate to determine the most appropriate clinical role of PHVR or the specific patient populations for whom it might eventually be indicated.
Remy R Coeytaux; John W Williams; Rebecca N Gray; Andrew Wang
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review     Date:  2010-08-02
Journal Detail:
Title:  Annals of internal medicine     Volume:  153     ISSN:  1539-3704     ISO Abbreviation:  Ann. Intern. Med.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-07     Completed Date:  2010-09-20     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  0372351     Medline TA:  Ann Intern Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  314-24     Citation Subset:  AIM; IM    
Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27715, USA.
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MeSH Terms
Aortic Valve Stenosis / surgery*
Cardiac Catheterization*
Evidence-Based Medicine
Heart Valve Prosthesis
Heart Valve Prosthesis Implantation / methods*
Prosthesis Design
Treatment Outcome
United States

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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