| Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China. | |
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MedLine Citation:
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PMID: 21866560 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Narcolepsy is caused by the loss of hypocretin/orexin neurons in the hypothalamus, which is likely the result of an autoimmune process. Recently, concern has been raised over reports of narcolepsy in northern Europe following H1N1 vaccination. METHODS: The study is a retrospective analysis of narcolepsy onset in subjects diagnosed in Beijing, China (1998-2010). Self-reported month and year of onset were collected from 629 patients (86% children). Graphical presentation, autocorrelations, chi-square, and Fourier analysis were used to assess monthly variation in onset. Finally, 182 patients having developed narcolepsy after October 2009 were asked for vaccination history. RESULTS: The occurrence of narcolepsy onset was seasonal, significantly influenced by month and calendar year. Onset was least frequent in November and most frequent in April, with a 6.7-fold increase from trough to peak. Studying year-to-year variation, we found a 3-fold increase in narcolepsy onset following the 2009 H1N1 winter influenza pandemic. The increase is unlikely to be explained by increased vaccination, as only 8 of 142 (5.6%) patients recalled receiving an H1N1 vaccination. Cross-correlation indicated a significant 5- to 7-month delay between the seasonal peak in influenza/cold or H1N1 infections and peak in narcolepsy onset occurrences. INTERPRETATION: In China, narcolepsy onset is highly correlated with seasonal and annual patterns of upper airway infections, including H1N1 influenza. In 2010, the peak seasonal onset of narcolepsy was phase delayed by 6 months relative to winter H1N1 infections, and the correlation was independent of H1N1 vaccination in the majority of the sample. |
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Authors:
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Fang Han; Ling Lin; Simon C Warby; Juliette Faraco; Jing Li; Song X Dong; Pei An; Long Zhao; Ling H Wang; Qian Y Li; Han Yan; Zhan C Gao; Yuan Yuan; Kingman P Strohl; Emmanuel Mignot |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2011-08-22 |
Journal Detail:
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Title: Annals of neurology Volume: 70 ISSN: 1531-8249 ISO Abbreviation: Ann. Neurol. Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-09-09 Completed Date: 2011-10-31 Revised Date: 2011-11-11 |
Medline Journal Info:
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Nlm Unique ID: 7707449 Medline TA: Ann Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 410-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 American Neurological Association. |
Affiliation:
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Department of Pulmonary Medicine, Beijing University People's Hospital, Beijing, China. hanfang1@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Child China / epidemiology Common Cold / epidemiology Data Interpretation, Statistical Female Humans Influenza A Virus, H1N1 Subtype* Influenza Vaccines Influenza, Human / epidemiology* Male Middle Aged Narcolepsy / epidemiology* Pandemics Polysomnography Retrospective Studies Seasons* Vaccination / statistics & numerical data Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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NIH-NS23724/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Influenza Vaccines |
| Comments/Corrections | |
Comment In:
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Nat Rev Neurol. 2011;7(10):537
[PMID:
21984118
]
Ann Neurol. 2011 Sep;70(3):A5-6 [PMID: 21866561 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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