Document Detail


Naptumomab estafenatox: a new immunoconjugate.
MedLine Citation:
PMID:  20053143     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
IMPORTANCE OF THE FIELD: New agents that specifically engage the immune system are being tested in a variety of malignancies. This review provides an overview of naptumomab, an immunotoxin, with encouraging clinical activity in Phase I trials. AREAS COVERED IN THIS REVIEW: This review examines the preclinical and the published clinical data with regards to naptumomab. WHAT THE READER WILL GAIN: This review provides the reader with an understanding of the mechanism of action, immunology, pharmacokinetics and clinical activity of this agent. TAKE HOME MESSAGE: Naptumomab has a unique mechanism of action and appears to be an active agent in the treatment of refractory solid tumors such as renal cell carcinoma.
Authors:
Matthew K Robinson; R Katherine Alpaugh; Hossein Borghaei
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert opinion on biological therapy     Volume:  10     ISSN:  1744-7682     ISO Abbreviation:  Expert Opin Biol Ther     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-21     Completed Date:  2010-04-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101125414     Medline TA:  Expert Opin Biol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  273-9     Citation Subset:  IM    
Affiliation:
Fox Chase Cancer Center, Department of Medical Oncology, 333 Cottman Ave, Philadelphia, PA 19111, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Monoclonal / adverse effects,  chemistry,  pharmacokinetics,  pharmacology,  therapeutic use*
Antineoplastic Agents / adverse effects,  chemistry,  pharmacokinetics,  pharmacology,  therapeutic use*
Clinical Trials, Phase I as Topic
Drug Design
Enterotoxins / adverse effects,  chemistry,  pharmacokinetics,  pharmacology,  therapeutic use*
Humans
Immunoconjugates / adverse effects,  chemistry,  pharmacokinetics,  pharmacology,  therapeutic use*
Neoplasms / drug therapy*
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antineoplastic Agents; 0/Enterotoxins; 0/Immunoconjugates; 676258-98-3/naptumomab estafenatox

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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