| Napsin a expression in primary mucin-producing adenocarcinomas of the lung: an immunohistochemical study. | |
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MedLine Citation:
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PMID: 23355200 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Immunohistochemical expression of napsin A in primary pulmonary mucinous tumors is not well established. Napsin A immunoreactivity was evaluated in 43 mucin-producing adenocarcinomas of the lung consisting of 18 tumors formerly classified as mucinous bronchioloalveolar carcinoma, 15 colloid adenocarcinomas, 5 solid predominant adenocarcinomas with mucin production, and 5 adenocarcinomas with signet ring cell features, as well as in 25 extrapulmonary mucinous adenocarcinomas of different anatomic sites. Immunohistochemical expression of thyroid transcription factor 1 (TTF-1) was also compared. Thirty-three percent of mucinous lung tumors exhibited positive immunoreactivity for napsin A, whereas 42% expressed TTF-1. All 25 extrapulmonary mucinous adenocarcinomas lacked expression of napsin A and TTF-1. Mucin-producing neoplasms of the lung infrequently express napsin A, suggesting that immunohistochemical assessment of napsin A may have limited diagnostic usefulness for distinguishing primary and metastatic mucinous adenocarcinomas involving the lung. |
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Authors:
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Jeffrey Wu; Peiguo G Chu; Zhong Jiang; Sean K Lau |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of clinical pathology Volume: 139 ISSN: 1943-7722 ISO Abbreviation: Am. J. Clin. Pathol. Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-01-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370470 Medline TA: Am J Clin Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 160-6 Citation Subset: AIM; IM |
Affiliation:
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Dept of Pathology, Kaiser Foundation Hospital, Orange County-Anaheim, 3440 East La Palma Ave, Anaheim, CA 92806; Sean.K.Lau@kp.org. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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