Document Detail

Naphthopyranone glycosides from Paepalanthus microphyllus.
MedLine Citation:
PMID:  11374977     Owner:  NLM     Status:  MEDLINE    
Three new naphthopyranone glycosides, paepalantine-9-O-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranoside (1), paepalantine-9-O-alpha-L-arabinopyranosyl-(1-->6)-beta-D-glucopyranoside (2), and paepalantine-9-O-alpha-L-rhamnopyranosyl-(1-->6)-beta-D-glucopyranoside (3), along with the known paepalantine-9-O-beta-D-glucopyranoside (4) were isolated from aerial parts of Paepalanthus microphyllus. These compounds were characterized by spectrometric methods, including electrospray mass spectrometry and 1D and 2D NMR experiments. As a part of our program for screening natural compounds for anti-HIV activity, compounds 1-4 were tested in C8166 cells infected with HIV-1MN.
S Piacente; L Campaner Dos Santos; N Mahmood; A Zampelli; C Pizza; W Vilegas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of natural products     Volume:  64     ISSN:  0163-3864     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-05-25     Completed Date:  2001-09-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  680-2     Citation Subset:  IM    
Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Via Ponte Don Melillo 84084, Fisciano, SA, Italy.
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MeSH Terms
Anti-HIV Agents / chemistry*,  isolation & purification,  pharmacology
Drug Evaluation, Preclinical
Glycosides / chemistry*,  isolation & purification,  pharmacology
HIV-1 / drug effects
Magnetic Resonance Spectroscopy
Plants, Medicinal / chemistry*
Spectrometry, Mass, Electrospray Ionization
Spectrophotometry, Ultraviolet
Reg. No./Substance:
0/Anti-HIV Agents; 0/Glycosides

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