Document Detail


Nantenine alkaloid presents anticonvulsant effect on two classical animal models.
MedLine Citation:
PMID:  13678244     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study investigated the anticonvulsant and convulsant profiles of nantenine, an aporphine alkaloid found in several vegetal species. At lower doses (20-50 mg/kg, i.p.) the alkaloid proved to be effective in inhibiting pentylenotetrazol- (PTZ 100 mg/kg, s.c.) and maximal electroshock-induced seizures (80 mA, 50 pulses/s, 0.2 s), suggesting its potential as an anticonvulsant drug. However, at higher doses (> or = 75 mg/kg, i.p.) a convulsant activity was observed. Comparing the present in vivo nantenine effects on seizures with previous in vitro biphasic action on Na+, K+-ATPase activity, the convulsant effect appears to be related to inhibition of these phosphatase at high doses whereas anticonvulsant effect, observed at low doses, seems attributable to its stimulation and the resultant decrease of Ca2+-influx into the cell.
Authors:
R A Ribeiro; J R Leite
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Phytomedicine : international journal of phytotherapy and phytopharmacology     Volume:  10     ISSN:  0944-7113     ISO Abbreviation:  Phytomedicine     Publication Date:  2003  
Date Detail:
Created Date:  2003-09-18     Completed Date:  2004-01-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9438794     Medline TA:  Phytomedicine     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  563-8     Citation Subset:  IM    
Affiliation:
Departamento de Farmacologia, Universidade Federal de São Paulo, Escola Paulista de Medicina, Rua Botucatu 862, Edifício José Leal Prado, São Paulo, Brazil. rosanari@terra.com.br
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MeSH Terms
Descriptor/Qualifier:
Alkaloids / administration & dosage,  pharmacology*,  therapeutic use
Animals
Anticonvulsants / administration & dosage,  pharmacology*,  therapeutic use
Aporphines / administration & dosage,  pharmacology*,  therapeutic use
Disease Models, Animal
Dose-Response Relationship, Drug
Electricity
Humans
Male
Mice
Pentylenetetrazole / diagnostic use
Phytotherapy*
Plants, Medicinal*
Seizures / chemically induced,  prevention & control*
Chemical
Reg. No./Substance:
0/Alkaloids; 0/Anticonvulsants; 0/Aporphines; 2565-01-7/nantenine; 54-95-5/Pentylenetetrazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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