| Nanotechnology for synthetic high-density lipoproteins. | |
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MedLine Citation:
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PMID: 21087901 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Atherosclerosis is the disease mechanism responsible for coronary heart disease (CHD), the leading cause of death worldwide. One strategy to combat atherosclerosis is to increase the amount of circulating high-density lipoproteins (HDL), which transport cholesterol from peripheral tissues to the liver for excretion. The process, known as reverse cholesterol transport, is thought to be one of the main reasons for the significant inverse correlation observed between HDL blood levels and the development of CHD. This article highlights the most common strategies for treating atherosclerosis using HDL. We further detail potential treatment opportunities that utilize nanotechnology to increase the amount of HDL in circulation. The synthesis of biomimetic HDL nanostructures that replicate the chemical and physical properties of natural HDL provides novel materials for investigating the structure-function relationships of HDL and for potential new therapeutics to combat CHD. |
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Authors:
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Andrea J Luthi; Pinal C Patel; Caroline H Ko; R Kannan Mutharasan; Chad A Mirkin; C Shad Thaxton |
Publication Detail:
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Type: Journal Article Date: 2010-11-17 |
Journal Detail:
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Title: Trends in molecular medicine Volume: 16 ISSN: 1471-499X ISO Abbreviation: Trends Mol Med Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100966035 Medline TA: Trends Mol Med Country: England |
Other Details:
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Languages: eng Pagination: 553-60 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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