| Nanotechnologies for biomolecular detection and medical diagnostics. | |
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MedLine Citation:
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PMID: 16418011 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nanotechnology-based platforms for the high-throughput, multiplexed detection of proteins and nucleic acids in heretofore unattainable abundance ranges promise to bring substantial advances in molecular medicine. The emerging approaches reviewed in this article, with reference to their diagnostic potential, include nanotextured surfaces for proteomics, a two-particle sandwich assay for the biological amplification of low-concentration biomolecular signals, and silicon-based nanostructures for the transduction of molecular binding into electrical and mechanical signals, respectively. |
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Authors:
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Mark Ming-Cheng Cheng; Giovanni Cuda; Yuri L Bunimovich; Marco Gaspari; James R Heath; Haley D Hill; Chad A Mirkin; A Jasper Nijdam; Rosa Terracciano; Thomas Thundat; Mauro Ferrari |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review Date: 2006-01-18 |
Journal Detail:
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Title: Current opinion in chemical biology Volume: 10 ISSN: 1367-5931 ISO Abbreviation: Curr Opin Chem Biol Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-02-13 Completed Date: 2006-05-16 Revised Date: 2009-08-25 |
Medline Journal Info:
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Nlm Unique ID: 9811312 Medline TA: Curr Opin Chem Biol Country: England |
Other Details:
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Languages: eng Pagination: 11-9 Citation Subset: IM |
Affiliation:
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Division of Hematology and Oncology, Internal Medicine, The Ohio State University, 473 West 12 Avenue, Columbus OH 43210-1002, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biopolymers
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chemistry* Diagnostic Techniques and Procedures / instrumentation* Humans Nanostructures / chemistry Nanotechnology / instrumentation, methods* Protein Array Analysis / instrumentation, methods Sensitivity and Specificity Silicon / chemistry Surface Properties |
| Grant Support | |
ID/Acronym/Agency:
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N01-CO-12400/CO/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biopolymers; 7440-21-3/Silicon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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