Document Detail


Nanotech-derived topical microbicides for HIV prevention: The road to clinical development.
MedLine Citation:
PMID:  25446339     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
More than three decades since its discovery, HIV infection remains one of the most aggressive epidemics worldwide, with more than 35 million people infected. In sub-Saharan Africa, heterosexual transmissions represent nearly 80% of new infections, with 50% of these occurring in women. In an effort to stop the dramatic spread of the HIV epidemic, new preventive treatments, such as microbicides, have been developed. Nanotechnology has revolutionized this field by designing and engineering novel highly effective nano-sized materials as microbicide candidates. This review illustrates the most recent advances in nanotech-derived HIV prevention strategies, as well as the main steps required to translate promising in vitro results into clinical trials.
Authors:
Javier Sánchez-Rodríguez; Enrique Vacas-Córdoba; Rafael Gómez; F Javier De La Mata; Ma Ángeles Muñoz-Fernández
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Publication Detail:
Type:  REVIEW     Date:  2014-11-7
Journal Detail:
Title:  Antiviral research     Volume:  113C     ISSN:  1872-9096     ISO Abbreviation:  Antiviral Res.     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-12-2     Completed Date:  -     Revised Date:  2014-12-3    
Medline Journal Info:
Nlm Unique ID:  8109699     Medline TA:  Antiviral Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  33-48     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier B.V. All rights reserved.
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