Document Detail

Nanostructured, highly aligned poly(hydroxy butyrate) electrospun fibers for differentiation of skeletal and cardiac muscle cells.
MedLine Citation:
PMID:  22255117     Owner:  NLM     Status:  MEDLINE    
The influence of novel nanostructured anisotropically electrospun poly(hydroxy butyrate) matrices on skeletal and cardiac muscle-like cell proliferation and differentiation was investigated, in comparison with isotropic and no-topographically cues-provided substrates. After the matrix characterization, in terms of surface SEM imaging and mechanical properties, cell differentiation on the different substrates was evaluated. Myogenin and F-actin staining at several differentiation time-points suggested that aligned nanofibers promote differentiation of both cell types. Moreover, quantitative parameters for each cell line are provided to clarify which aspects of the differentiation process are influenced by the different matrix topographies.
Leonardo Ricotti; Alessandro Polini; Giada G Genchi; Gianni Ciofani; Donata Iandolo; Virgilio Mattoli; Arianna Menciassi; Paolo Dario; Dario Pisignano
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference     Volume:  2011     ISSN:  1557-170X     ISO Abbreviation:  Conf Proc IEEE Eng Med Biol Soc     Publication Date:  2011  
Date Detail:
Created Date:  2012-01-18     Completed Date:  2012-06-20     Revised Date:  2014-08-21    
Medline Journal Info:
Nlm Unique ID:  101243413     Medline TA:  Conf Proc IEEE Eng Med Biol Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3597-600     Citation Subset:  IM    
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MeSH Terms
Bone and Bones / cytology,  drug effects*
Cell Differentiation / drug effects*
Heart / drug effects*
Hydroxybutyrates / chemistry,  pharmacology*
Polymers / chemistry,  pharmacology*
Reg. No./Substance:
0/Hydroxybutyrates; 0/Polymers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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