Document Detail

Nanostructure of the fibrin clot.
MedLine Citation:
PMID:  20923635     Owner:  NLM     Status:  MEDLINE    
The nanostructure of the fibrin fibers in fibrin clots is investigated by using spectrometry and small angle x-ray scattering measurements. First, an autocoherent analysis of the visible light spectra transmitted through formed clots is demonstrated to provide robust measurements of both the radius and density of the fibrin fibers. This method is validated via comparison with existing small-angle and dynamic light-scattering data. The complementary use of small angle x-ray scattering spectra and light spectrometry unambiguously shows the disjointed nature of the fibrin fibers. Indeed, under quasiphysiological conditions, the fibers are approximately one-half as dense as their crystalline fiber counterparts. Further, although the fibers are locally crystalline, they appear to possess a lateral fractal structure.
C Yeromonahos; B Polack; F Caton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biophysical journal     Volume:  99     ISSN:  1542-0086     ISO Abbreviation:  Biophys. J.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-06     Completed Date:  2011-01-20     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  0370626     Medline TA:  Biophys J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2018-27     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Biophysical Society. Published by Elsevier Inc. All rights reserved.
Centre National de la Recherche Scientifique, Université Joseph Fourier, Grenoble, France.
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MeSH Terms
Blood Coagulation / physiology*
Fibrin / chemistry*
Models, Molecular
Molecular Weight
Nanostructures / chemistry*
Nephelometry and Turbidimetry
Osmolar Concentration
Reproducibility of Results
Scattering, Small Angle
X-Ray Diffraction
Reg. No./Substance:
0/Solutions; 9001-31-4/Fibrin

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