| Nanosilver: application and novel aspects of toxicology. | |
| | |
MedLine Citation:
|
PMID: 23344422 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Nanomaterials are a challenge to toxicology. The high diversity of novel materials and products will require extensive expertize for evaluation and regulatory efforts. Nanomaterials are of substantial scientific and economic potential. Here, we will focus on nanosilver, a material not only with medical applications, but a rapidly increasing use in surprisingly many products. Consequently, toxicological evaluation has to cover an increasing range of complex topics. The toxicology of nanosilver is advancing rapidly; regulatory efforts by Federal Drug Agency and European Environment Protection Agencies are substantial. Current toxicological data, ranging from in vitro studies with cell lines to rodent experiments and ecological evaluation, are numerous, and many groups are providing continuously new data. However, standard classification based on nanosize only is neglecting nanoshape, which adds another level of complexity to the analysis of biological effects. A surprising neglect in nanosilver toxicology so far is the analysis of effects of nanosilver on amyloidosis. Amyloid diseases are widespread in humans and a severe health hazard. The known potential of silver to stimulate amyloidosis in rodents will require a timely and balanced evaluation of nanosilvers. |
| | |
Authors:
|
Jan K Schluesener; Hermann J Schluesener |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-1-24 |
Journal Detail:
|
Title: Archives of toxicology Volume: - ISSN: 1432-0738 ISO Abbreviation: Arch. Toxicol. Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-1-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0417615 Medline TA: Arch Toxicol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Division of Immunopathology of the Nervous System, Department of Neuropathology, Institute of Pathology and Neuropathology, University of Tuebingen, Calwer Str. 3, 72076, Tuebingen, Germany, jan.schluesener@gmail.com. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Recurrent Severe Oligohydramnios and Fetal Pulmonary Hypoplasia Associated With ErbB4 Mutation.
Next Document: Arthroscopic transtibial single-bundle posterior cruciate ligament reconstruction using patellar ten...