Document Detail


Nanopore sensors: From hybrid to abiotic systems.
MedLine Citation:
PMID:  22749726     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The use of nanopores of well controlled geometry for sensing molecules in solution is reviewed. Focus is concentrated especially on synthetic track-etch pores in polymer foils and on biological nanopores, i.e. ion channels. After a brief section about multipore sensors, specific attention is provided to works relative to a single nanopore sensor. The different strategies to combine the robustness of supports with the high selectivity of the biological channels are reviewed. The scope ranges from keeping the membrane natural environment of biological channels in supported and suspended bilayer membranes, to considering completely abiotic designed nanopores created through synthetic materials. The α-hemolysine channel and the mechanosensitive channel of large conductance with their modifications are especially considered in the first strategy, the conical functionalized nanopores created in polymer foils in the second one. The different attempts of reading macromolecules are also discussed. A third hybrid strategy, which was not extensively explored, consists in the inclusion of a biological structure into a well-designed nanopore through the support, as recently with gramicidin.
Authors:
Armagan Kocer; Lara Tauk; Philippe Déjardin
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-19
Journal Detail:
Title:  Biosensors & bioelectronics     Volume:  -     ISSN:  1873-4235     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-7-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9001289     Medline TA:  Biosens Bioelectron     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Affiliation:
Biomade Technology Foundation, Nijenborgh 4, 9747 AG, Groningen, The Netherlands; Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands.
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