Document Detail


Nanoparticulate carriers (NPC) for oral pharmaceutics and nutraceutics.
MedLine Citation:
PMID:  20225647     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The introduction of nanoparticulate carriers (NPC) in the pharmaceutic and nutraceutic fields has changed the definitions of disease management and treatment, diagnosis, as well as the supply food chain in the agri-food sector. NPC composed of synthetic polymers, proteins or polysaccharides gather interesting properties to be used for oral administration of pharmaceutics and nutraceutics. Oral administration remains the most convenient way of delivering drugs (e.g. peptides, proteins and nucleic acids) since these suffer similar metabolic pathways as food supply. Recent advances in biotechnology have produced highly potent new molecules however with low oral bioavailability. A suitable and promising approach to overcome their sensitivity to chemical and enzymatic hydrolysis as well as the poor cellular uptake, would be their entrapment within suitable gastrointestinal (GI) resistant NPC. Increasing attention has been paid to the potential use of NPC for peptides, proteins, antioxidants (carotenoids, omega fatty acids, coenzyme Q10), vitamins, probiotics, for oral administration. This review focuses on the most important materials to produce NPC for oral administration, and the most recent achievements in the production techniques and bioactives successfully delivered by these means.
Authors:
C M Lopes; P Martins-Lopes; E B Souto
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Die Pharmazie     Volume:  65     ISSN:  0031-7144     ISO Abbreviation:  Pharmazie     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-03-15     Completed Date:  2010-04-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9800766     Medline TA:  Pharmazie     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  75-82     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutical Technology, Faculty of Health Sciences, Fernando Pessoa University, Porto, Portugal.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Albumins / chemistry
Animals
Chemistry, Pharmaceutical
Dietary Supplements / analysis*
Drug Carriers*
Excipients
Gelatin / chemistry
Humans
Nanoparticles*
Pharmaceutical Preparations / administration & dosage*
Polymers
Polysaccharides / chemistry
Chemical
Reg. No./Substance:
0/Albumins; 0/Drug Carriers; 0/Excipients; 0/Pharmaceutical Preparations; 0/Polymers; 0/Polysaccharides; 9000-70-8/Gelatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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