Document Detail


The Nanoparticulate Quillaja Saponin BBE is selectively active towards renal cell carcinoma.
MedLine Citation:
PMID:  23267139     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To characterize the cytotoxic effect of BBE, the particulate of desacyl-saponin, in model systems of solid tumours.
MATERIALS AND METHODS: Cytotoxic activity of BBE was investigated in solid human tumour cell lines, in tumour cells from patients with renal cell carcinoma, in normal human renal cells and in peripheral blood mononuclear cells. The BBE mode of cell death was assessed in vitro. In vivo effect of BBE was evaluated in xenograft-bearing mice.
RESULTS: BBE was selectively active against renal cell carcinoma, with no or little effect on normal cells. BBE induced caspase activity and apoptosis. An inhibitory activity of BBE on xenograft tumour growth, with no apparent signs of haematological toxicity was shown. In the non-proliferative model of patient tumour cells, BBE was active on only 1/5 patient samples, suggesting association of BBE effect with cell proliferation.
CONCLUSION: BBE has interesting activities against renal cell carcinoma and should be further explored as a drug against this resistant tumour type.
Authors:
Saadia B Hassan; Joachim Gullbo; Kefei Hu; Saideh Berenjian; Bror Morein; Peter Nygren
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anticancer research     Volume:  33     ISSN:  1791-7530     ISO Abbreviation:  Anticancer Res.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-25     Completed Date:  2013-05-30     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  143-51     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis / drug effects
Carcinoma, Renal Cell / drug therapy
Cell Line, Tumor
Cell Proliferation / drug effects*
Drug Resistance, Neoplasm
Female
Humans
Kidney Neoplasms / drug therapy
Mice
Mice, Nude
Nanoparticles / administration & dosage
Plant Extracts* / administration & dosage,  chemistry
Quillaja / chemistry*
Quillaja Saponins / administration & dosage*
Transplantation, Heterologous
Chemical
Reg. No./Substance:
0/Plant Extracts; 0/Quillaja Saponins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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