Document Detail


Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy.
MedLine Citation:
PMID:  19376175     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Proteins bind the surfaces of nanoparticles, and biological materials in general, immediately upon introduction of the materials into a physiological environment. The further biological response of the body is influenced by the nanoparticle-protein complex. The nanoparticle's composition and surface chemistry dictate the extent and specificity of protein binding. Protein binding is one of the key elements that affects biodistribution of the nanoparticles throughout the body. Here we review recent research on nanoparticle physicochemical properties important for protein binding, techniques for isolation and identification of nanoparticle-bound proteins, and how these proteins can influence particle biodistribution and biocompatibility. Understanding the nanoparticle-protein complex is necessary for control and manipulation of protein binding, and allows for improved engineering of nanoparticles with favorable bioavailability and biodistribution.
Authors:
Parag Aggarwal; Jennifer B Hall; Christopher B McLeland; Marina A Dobrovolskaia; Scott E McNeil
Related Documents :
23521725 - Specificity and regulation of the endoplasmic reticulum-associated degradation machinery.
22923435 - Molecular mechanics of cardiac myosin-binding protein c in native thick filaments.
16674185 - Bioenzymatic detection of troponin c using micro-opto-electro-mechanical systems.
15741075 - Langmuir monolayer approaches to protein recognition through molecular imprinting.
1912395 - Fibronectin mrna and protein accumulation, distribution, and breakdown in rabbit anti-g...
2668695 - Topology and function of the integral membrane protein conferring immunity to colicin a.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2009-04-17
Journal Detail:
Title:  Advanced drug delivery reviews     Volume:  61     ISSN:  1872-8294     ISO Abbreviation:  Adv. Drug Deliv. Rev.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-29     Completed Date:  2009-08-31     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  8710523     Medline TA:  Adv Drug Deliv Rev     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  428-37     Citation Subset:  IM    
Affiliation:
Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC-Frederick Inc., NCI-Frederick, Frederick, MD 21702, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Blood Proteins / analysis,  chemistry,  metabolism*
Drug Carriers / metabolism,  pharmacokinetics*,  therapeutic use*
Humans
Kinetics
Nanoparticles / chemistry*
Protein Binding / physiology
Tissue Distribution
Grant Support
ID/Acronym/Agency:
HHSN261200800001E/CO/NCI NIH HHS; N01-CO-12400/CO/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Blood Proteins; 0/Drug Carriers
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Spatial regulation of specific gene expression through photoactivation of RNAi.
Next Document:  Poly(ADP-ribose) polymerase activity in systemic lupus erythematosus and systemic sclerosis.