Document Detail

Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy.
MedLine Citation:
PMID:  19376175     Owner:  NLM     Status:  MEDLINE    
Proteins bind the surfaces of nanoparticles, and biological materials in general, immediately upon introduction of the materials into a physiological environment. The further biological response of the body is influenced by the nanoparticle-protein complex. The nanoparticle's composition and surface chemistry dictate the extent and specificity of protein binding. Protein binding is one of the key elements that affects biodistribution of the nanoparticles throughout the body. Here we review recent research on nanoparticle physicochemical properties important for protein binding, techniques for isolation and identification of nanoparticle-bound proteins, and how these proteins can influence particle biodistribution and biocompatibility. Understanding the nanoparticle-protein complex is necessary for control and manipulation of protein binding, and allows for improved engineering of nanoparticles with favorable bioavailability and biodistribution.
Parag Aggarwal; Jennifer B Hall; Christopher B McLeland; Marina A Dobrovolskaia; Scott E McNeil
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2009-04-17
Journal Detail:
Title:  Advanced drug delivery reviews     Volume:  61     ISSN:  1872-8294     ISO Abbreviation:  Adv. Drug Deliv. Rev.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-29     Completed Date:  2009-08-31     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  8710523     Medline TA:  Adv Drug Deliv Rev     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  428-37     Citation Subset:  IM    
Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC-Frederick Inc., NCI-Frederick, Frederick, MD 21702, USA.
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MeSH Terms
Blood Proteins / analysis,  chemistry,  metabolism*
Drug Carriers / metabolism,  pharmacokinetics*,  therapeutic use*
Nanoparticles / chemistry*
Protein Binding / physiology
Tissue Distribution
Grant Support
HHSN261200800001E/CO/NCI NIH HHS; N01-CO-12400/CO/NCI NIH HHS
Reg. No./Substance:
0/Blood Proteins; 0/Drug Carriers

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