| Nanomolar concentrations of Bowman-Birk soybean protease inhibitor suppress x-ray-induced transformation in vitro. | |
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MedLine Citation:
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PMID: 3860869 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Experiments reported here indicate a crude soybean extract, if defatted with acetone, effectively blocks cell transformation in vitro. An active component of this crude extract is the Bowman-Birk trypsin and chymotrypsin inhibitor. The chymotrypsin-inhibitory region of the Bowman-Birk inhibitor is responsible for suppressing in vitro transformation. Another low molecular weight soybean trypsin inhibitor does not significantly suppress transformation. The Bowman-Birk inhibitor (i) has an irreversible effect on the transformation process, (ii) can suppress radiation-induced transformation even when added to cultures many days after the carcinogen exposure, and (iii) is effective in its ability to suppress transformation when present in the medium at a concentration as low as 0.125 nM. |
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Authors:
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J Yavelow; M Collins; Y Birk; W Troll; A R Kennedy |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 82 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 1985 Aug |
Date Detail:
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Created Date: 1985-09-25 Completed Date: 1985-09-25 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 5395-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetone
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pharmacology Animals Cell Transformation, Neoplastic / drug effects* Cells, Cultured Chymotrypsin / antagonists & inhibitors Mice Mice, Inbred C3H Trypsin Inhibitor, Bowman-Birk Soybean / pharmacology* Trypsin Inhibitors / pharmacology* X-Rays |
| Grant Support | |
ID/Acronym/Agency:
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CA-22704/CA/NCI NIH HHS; ES-00002/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Trypsin Inhibitor, Bowman-Birk Soybean; 0/Trypsin Inhibitors; 67-64-1/Acetone; EC 3.4.21.1/Chymotrypsin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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