Document Detail


Nanomicelle with long-term circulation and enhanced stability of camptothecin based on mPEGylated alpha,beta-poly (L-aspartic acid)-camptothecin conjugate.
MedLine Citation:
PMID:  20674289     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
To enhance the stability and long-term circulation of camptothecin (CPT), mPEGylated alpha,beta-poly (L-aspartic acid)-CPT conjugates were synthesized, and used to fabricate nanomicelle. Firstly, alpha,beta-poly (L-aspartic acid) derivative (PAA-der) containing alkyne groups was synthesized via the ring-opening of PSI with propargyl amine. And then, azide-functionalized CPT derivatives (CPT-N(3)) and azide-terminated poly (ethylene glycol) methyl ether (mPEG-N(3)) were conjugated with PAA-der by click cycloaddition to give mPEG-graft-PAA-CPT conjugates. The formation of mPEG-graft-PAA-CPT nanomicelles was confirmed by fluorescence spectrophotoscopy and particle size measurements. It was found that all the nanomicelles showed spherical shapes with size about 178 nm. MPEG-graft-PAA-CPT nanomicelles showed good storage stability, even incubation at 37 degrees C for 60 days, and improved the stability of CPT lactone form in aqueous media. A steady release rate of CPT was kept for 72h, suggested the great potential of mPEG-graft-PAA-CPT nanomicelles as polymer prodrug of CPT.
Authors:
Weilu Zhang; Jin Huang; Naiqian Fan; Jiahui Yu; Yongbiao Liu; Shiyuan Liu; Daxin Wang; Yaping Li
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-15
Journal Detail:
Title:  Colloids and surfaces. B, Biointerfaces     Volume:  81     ISSN:  1873-4367     ISO Abbreviation:  Colloids Surf B Biointerfaces     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-08-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9315133     Medline TA:  Colloids Surf B Biointerfaces     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  297-303     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier B.V. All rights reserved.
Affiliation:
Institutes for Advanced Interdisciplinary Research, East China Normal University, 3663# North Zhongshan Road, Shanghai 200062, PR China.
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