| Nanomicelle with long-term circulation and enhanced stability of camptothecin based on mPEGylated alpha,beta-poly (L-aspartic acid)-camptothecin conjugate. | |
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MedLine Citation:
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PMID: 20674289 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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To enhance the stability and long-term circulation of camptothecin (CPT), mPEGylated alpha,beta-poly (L-aspartic acid)-CPT conjugates were synthesized, and used to fabricate nanomicelle. Firstly, alpha,beta-poly (L-aspartic acid) derivative (PAA-der) containing alkyne groups was synthesized via the ring-opening of PSI with propargyl amine. And then, azide-functionalized CPT derivatives (CPT-N(3)) and azide-terminated poly (ethylene glycol) methyl ether (mPEG-N(3)) were conjugated with PAA-der by click cycloaddition to give mPEG-graft-PAA-CPT conjugates. The formation of mPEG-graft-PAA-CPT nanomicelles was confirmed by fluorescence spectrophotoscopy and particle size measurements. It was found that all the nanomicelles showed spherical shapes with size about 178 nm. MPEG-graft-PAA-CPT nanomicelles showed good storage stability, even incubation at 37 degrees C for 60 days, and improved the stability of CPT lactone form in aqueous media. A steady release rate of CPT was kept for 72h, suggested the great potential of mPEG-graft-PAA-CPT nanomicelles as polymer prodrug of CPT. |
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Authors:
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Weilu Zhang; Jin Huang; Naiqian Fan; Jiahui Yu; Yongbiao Liu; Shiyuan Liu; Daxin Wang; Yaping Li |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-15 |
Journal Detail:
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Title: Colloids and surfaces. B, Biointerfaces Volume: 81 ISSN: 1873-4367 ISO Abbreviation: Colloids Surf B Biointerfaces Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-08-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9315133 Medline TA: Colloids Surf B Biointerfaces Country: Netherlands |
Other Details:
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Languages: eng Pagination: 297-303 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Institutes for Advanced Interdisciplinary Research, East China Normal University, 3663# North Zhongshan Road, Shanghai 200062, PR China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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