| Nanomedicine for uterine leiomyoma therapy. | |
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MedLine Citation:
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PMID: 23343157 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background: The purpose of this work was to engineer polymeric nanoparticles to encapsulate and deliver 2-methoxyestradiol, a potential antitumor drug for treatment of uterine leiomyoma (fibroids), the most common hormone-dependent pathology affecting women of reproductive age. Methods/Results: Encapsulation efficiency and drug release from the nanoparticles were monitored by HPLC. Cell morphology and in vitro cytotoxicity experiments were carried out in a human leiomyoma cell line. The nanoparticles displayed high encapsulation efficiency (>86%), which was verified by differential scanning calorimetry and x-ray diffraction. Excellent long-term stability of the nanoparticles and gradual drug release without burst were also observed. Cellular uptake of fluorescent nanoparticles was confirmed by confocal imaging. The drug-loaded poly(lactic acid) and poly(lactic-co-glycolic acid) nanoparticles induced cytotoxicity in human leiomyoma cells to a significantly greater extent than the free drug at 0.35 µM. Conclusion: This novel approach represents a potential fertility-preserving alternative to hysterectomy. |
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Authors:
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Hazem Ali; Gokhan Kilic; Kathleen Vincent; Massoud Motamedi; Erik Rytting |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Therapeutic delivery Volume: 4 ISSN: 2041-5990 ISO Abbreviation: Ther Deliv Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-01-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101538870 Medline TA: Ther Deliv Country: England |
Other Details:
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Languages: eng Pagination: 161-75 Citation Subset: IM |
Affiliation:
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Department of Obstetrics & Gynecology, University of Texas Medical Branch, Galveston, TX 77555, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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