Document Detail

Nanomechanical properties of phospholipid microbubbles.
MedLine Citation:
PMID:  22313122     Owner:  NLM     Status:  MEDLINE    
This study uses atomic force microscopy (AFM) force-deformation (F-Δ) curves to investigate for the first time the Young's modulus of a phospholipid microbubble (MB) ultrasound contrast agent. The stiffness of the MBs was calculated from the gradient of the F-Δ curves, and the Young's modulus of the MB shell was calculated by employing two different mechanical models based on the Reissner and elastic membrane theories. We found that the relatively soft phospholipid-based MBs behave inherently differently to stiffer, polymer-based MBs [Glynos, E.; Koutsos, V.; McDicken, W. N.; Moran, C. M.; Pye, S. D.; Ross, J. A.; Sboros, V. Langmuir2009, 25 (13), 7514-7522] and that elastic membrane theory is the most appropriate of the models tested for evaluating the Young's modulus of the phospholipid shell, agreeing with values available for living cell membranes, supported lipid bilayers, and synthetic phospholipid vesicles. Furthermore, we show that AFM F-Δ curves in combination with a suitable mechanical model can assess the shell properties of phospholipid MBs. The "effective" Young's modulus of the whole bubble was also calculated by analysis using Hertz theory. This analysis yielded values which are in agreement with results from studies which used Hertz theory to analyze similar systems such as cells.
Evelyn Buchner Santos; Julia K Morris; Emmanouil Glynos; Vassilis Sboros; Vasileios Koutsos
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-03-22
Journal Detail:
Title:  Langmuir : the ACS journal of surfaces and colloids     Volume:  28     ISSN:  1520-5827     ISO Abbreviation:  Langmuir     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-03     Completed Date:  2012-08-07     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  9882736     Medline TA:  Langmuir     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5753-60     Citation Subset:  IM    
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MeSH Terms
Contrast Media / chemistry
Elastic Modulus*
Microscopy, Atomic Force*
Phospholipids / chemistry*
Grant Support
PG/10/21/28254//British Heart Foundation
Reg. No./Substance:
0/Contrast Media; 0/Phospholipids

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