Document Detail

Nanomaterial-mediated CNS delivery of diagnostic and therapeutic agents.
MedLine Citation:
PMID:  22178615     Owner:  NLM     Status:  MEDLINE    
Research into the diagnosis and treatment of central nervous system (CNS) diseases has been enhanced by rapid advances in nanotechnology and an expansion in the library of nanostructured carriers. This review discusses the latest applications of nanomaterials in the CNS with an emphasis on brain tumors. Novel administration routes and transport mechanisms for nanomaterial-mediated CNS delivery of diagnostic and therapeutic agents to bypass or cross the blood brain barrier (BBB) are also discussed. These include temporary disruption of the BBB, use of impregnated polymers (polymer wafers), convection-enhanced delivery (CED), and intranasal delivery. Moreover, an in vitro BBB model capable of mimicking geometrical, cellular and rheological features of the human cerebrovasculature has been developed. This is a useful tool that can be used for screening CNS nanoparticles or therapeutics prior to in vivo and clinical investigation. A discussion of this novel model is included.
Laura Biddlestone-Thorpe; Nicola Marchi; Kathy Guo; Chaitali Ghosh; Damir Janigro; Kristoffer Valerie; Hu Yang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2011-12-08
Journal Detail:
Title:  Advanced drug delivery reviews     Volume:  64     ISSN:  1872-8294     ISO Abbreviation:  Adv. Drug Deliv. Rev.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-24     Completed Date:  2013-01-28     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  8710523     Medline TA:  Adv Drug Deliv Rev     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  605-13     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
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MeSH Terms
Blood-Brain Barrier / drug effects,  metabolism
Central Nervous System / drug effects,  metabolism
Central Nervous System Diseases / diagnosis*,  drug therapy*,  metabolism
Drug Carriers / administration & dosage,  diagnostic use
Drug Delivery Systems / methods*
Nanoparticles / administration & dosage*,  diagnostic use*
Pharmaceutical Preparations / administration & dosage,  diagnostic use
Grant Support
P01 CA072955/CA/NCI NIH HHS; P01 CA072955-09/CA/NCI NIH HHS; P01CA72955/CA/NCI NIH HHS; R01 NS038195/NS/NINDS NIH HHS; R01 NS038195-04/NS/NINDS NIH HHS; R01 NS043284/NS/NINDS NIH HHS; R01 NS043284-04/NS/NINDS NIH HHS; R01 NS064593/NS/NINDS NIH HHS; R01 NS064593-04/NS/NINDS NIH HHS; R01NS064593/NS/NINDS NIH HHS; R01NS38195/NS/NINDS NIH HHS; R01NS43284/NS/NINDS NIH HHS; R21 CA156995/CA/NCI NIH HHS; R21 ES016636/ES/NIEHS NIH HHS; R21 ES016636-02/ES/NIEHS NIH HHS; R21 HD057256/HD/NICHD NIH HHS; R21 HD057256-02/HD/NICHD NIH HHS; R21 NS063200/NS/NINDS NIH HHS; R21 NS063200-02/NS/NINDS NIH HHS; R21ES016636/ES/NIEHS NIH HHS; R21HD057256/HD/NICHD NIH HHS; R21NS063200/NS/NINDS NIH HHS; R41 MH093302/MH/NIMH NIH HHS; R41 MH093302-01A2/MH/NIMH NIH HHS; R41MH093302/MH/NIMH NIH HHS; T32 CA113277/CA/NCI NIH HHS; T32 CA113277-05/CA/NCI NIH HHS; T32CA113277/CA/NCI NIH HHS
Reg. No./Substance:
0/Drug Carriers; 0/Pharmaceutical Preparations

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