| Nanoliter droplet viscometer with additive-free operation. | |
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MedLine Citation:
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PMID: 23192296 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Measurement of a solution's viscosity is an important analytic technique for a variety of applications including medical diagnosis, pharmaceutical development, and industrial processing. The use of droplet-based (e.g., water-in-oil) microfluidics for viscosity measurements allows nanoliter-scale sample volumes to be used, much smaller than those either in standard macro-scale rheometers or in single-phase microfluidic viscometers. By observing the flow rate of a sample plug driven by a controlled pressure through an abrupt constriction, we achieve accurate and precise measurement of the plug viscosity without addition of labels or tracer particles. Sample plugs in our device geometry had a volume of ∼30 nL, and measurements had an average error of 6.6% with an average relative standard deviation of 2.8%. We tested glycerol-based samples with viscosities as high as 101 mPa s, with the only limitation on samples being that their viscosity should be higher than that of the continuous oil phase. |
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Authors:
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Eric Livak-Dahl; Jaesung Lee; Mark A Burns |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-29 |
Journal Detail:
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Title: Lab on a chip Volume: - ISSN: 1473-0189 ISO Abbreviation: Lab Chip Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101128948 Medline TA: Lab Chip Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Chemical Engineering, University of Michigan, 3074 H. H. Dow, 2300 Hayward, Ann Arbor, MI 48109, USA. maburns@umich.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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