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Nanocoating of titanium implant surfaces with organic molecules. Polysaccharides including glycosaminoglycans.
MedLine Citation:
PMID:  23030010     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Long-term stability of titanium implants are dependent on a variety of factors. Nanocoating with organic molecules is one of the method used to improve osseointegration. Nanoscale modification of titanium implants affects surface properties, such as hydrophilicity, biochemical bonding capacity and roughness. This influences cell behaviour on the surface such as adhesion, proliferation and differentiation of cells as well as the mineralization of the extracellular matrix at the implant surfaces. The aim of the present systematic review was to describe organic molecules used for surface nanocoating with focus on polysaccharides including glycosaminoglycans, and how these molecules change surface properties, cell reactions and affect on osseointegartion. The included in vitro studies demonstrated increased cell adhesion, proliferation and mineralization of a number of the tested polysaccharide nanocoatings. The included in vivo studies, showed improvement of bone interface reactions measured as increased Bone-to-Implant Contact length and Bone Mineral Density adjacent to the polysaccharide coated surfaces. Based on existing literature, surface modification with polysaccharide and glycosaminoglycans appears to be an effective way to stimulate bone regeneration on bone-implant interface.
Authors:
Katarzyna Gurzawska; Rikke Svava; Niklas Rye Jørgensen; Klaus Gotfredsen
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of biomedical nanotechnology     Volume:  8     ISSN:  1550-7033     ISO Abbreviation:  J Biomed Nanotechnol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-10-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101230869     Medline TA:  J Biomed Nanotechnol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1012-24     Citation Subset:  IM    
Affiliation:
Research Center for Ageing and Osteoporosis, Department of Medicine and Clinical Biochemistry, Glostrup University Hospital, Ndr Ringvej 69, 2600 Glostrup, Denmark.
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