| Nanoceria extend photoreceptor cell lifespan in tubby mice by modulation of apoptosis/survival signaling pathways. | |
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MedLine Citation:
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PMID: 21396448 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cerium oxide nanoparticles, nanoceria, are inorganic antioxidants that have catalytic activities which mimic those of the neuroprotective enzymes superoxide dismutase and catalase. We have previously shown that nanoceria preserve retinal morphology and prevent loss of retinal function in a rat light damage model. In this study, the homozygous tubby mutant mouse, which exhibits inherited early progressive cochlear and retinal degeneration, was used as a model to test the ability of nanoceria to slow the progression of retinal degeneration. Tubby mice were injected systemically, intracardially, with 20 μl of 1mM nanoceria in saline, at postnatal day 10 and subsequently at P20 and P30 whereas saline injected and uninjected wild type (or heterozygous tubby) served as injected and uninjected controls, respectively. Assays for retinal function, morphology and signaling pathway gene expression were performed on P34 mice. Our data demonstrate that nanoceria protect the retina by decreasing Reactive Oxygen Species (ROS), up-regulating the expression of neuroprotection-associated genes; down-regulating apoptosis signaling pathways and/or up-regulating survival signaling pathways to slow photoreceptor degeneration. These data suggest that nanoceria have significant potential as global agents for therapeutic treatment of inherited retinal degeneration and most types of ocular diseases. |
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Authors:
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Li Kong; Xue Cai; Xiaohong Zhou; Lily L Wong; Ajay S Karakoti; Sudipta Seal; James F McGinnis |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2011-03-30 |
Journal Detail:
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Title: Neurobiology of disease Volume: 42 ISSN: 1095-953X ISO Abbreviation: Neurobiol. Dis. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-04-19 Completed Date: 2011-08-23 Revised Date: 2012-09-26 |
Medline Journal Info:
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Nlm Unique ID: 9500169 Medline TA: Neurobiol Dis Country: United States |
Other Details:
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Languages: eng Pagination: 514-23 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Ophthalmology/Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK73104, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Apoptosis / drug effects*, physiology Blotting, Western Cell Survival / drug effects*, physiology Cerium / administration & dosage* Electroretinography Mice Mice, Knockout Nanoparticles / administration & dosage* Photoreceptor Cells, Vertebrate / drug effects*, physiology Proteins / genetics Reactive Oxygen Species Retinal Degeneration / genetics, physiopathology, prevention & control* Reverse Transcriptase Polymerase Chain Reaction Signal Transduction / drug effects*, physiology |
| Grant Support | |
ID/Acronym/Agency:
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COBRE-P20 RR017703/RR/NCRR NIH HHS; P20 RR017703/RR/NCRR NIH HHS; P30 EY012190/EY/NEI NIH HHS; P30-EY12190/EY/NEI NIH HHS; R01 EY018724/EY/NEI NIH HHS; R01EY018724/EY/NEI NIH HHS; R21 EY018306/EY/NEI NIH HHS; R21EY018306/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Proteins; 0/Reactive Oxygen Species; 0/Tub protein, mouse; 1306-38-3/ceric oxide; 7440-45-1/Cerium |
| Comments/Corrections | |
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