| Nanocarriers: a tool to overcome biological barriers in siRNA delivery. | |
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MedLine Citation:
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PMID: 21682658 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Introduction: siRNA has poor in vivo stability and has a plasma half life of only a few minutes after intravenous administration. These problems can be overcome by conjugating/encapsulating siRNA with various nanosystems. Surface modifications of such nanosystems can further improve the cellular uptake of siRNA-nanosystems. In this review, the authors have highlighted the problems encountered in siRNA delivery, conjugation strategies and nanosystems for siRNA delivery and for improving their in vivo delivery performance. Areas covered: The authors briefly cover various problems encountered in siRNA delivery and discuss nanocarriers for overcoming these biological barriers. Expert opinion: siRNA binding and unpacking are important factors for optimizing the interactions between siRNA and nanosystems. Several crucial conjugation parameters, such as the conjugation site of siRNA, and the nature of molecules to be conjugated (charge, molecular weight and hydrophobicity), should be carefully considered for maximising delivery efficiency of siRNA conjugated nanosystems. |
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Authors:
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Avnesh Kumari; Vineet Kumar; Sudesh Kumar Yadav |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-20 |
Journal Detail:
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Title: Expert opinion on biological therapy Volume: - ISSN: 1744-7682 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101125414 Medline TA: Expert Opin Biol Ther Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Council of Scientific and Industrial Research (CSIR), Institute of Himalayan Bioresource Technology , Biotechnology Division, Nanobiology Lab, Palampur-176061 (HP) , India +91 9418050116 ; skyt@rediffmail.com; sudeshkumar@ihbt.res.in. |
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