Document Detail

Nanobubbles for enhanced ultrasound imaging of tumors.
MedLine Citation:
PMID:  22393289     Owner:  NLM     Status:  MEDLINE    
The fabrication and initial applications of nanobubbles (NBs) have shown promising results in recent years. A small particle size is a basic requirement for ultrasound contrast-enhanced agents that penetrate tumor blood vessel pores to allow for targeted imaging and therapy. However, the nanoscale size of the particles used has the disadvantage of weakening the imaging ability of clinical diagnostic ultrasound. In this work, we fabricated a lipid NBs contrast-enhanced ultrasound agent and evaluated its passive targeting ability in vivo. The results showed that the NBs were small (436.8 ± 5.7 nm), and in vitro ultrasound imaging suggested that the ultrasonic imaging ability is comparable to that of microbubbles (MBs). In vivo experiments confirmed the ability of NBs to passively target tumor tissues. The NBs remained in the tumor area for a longer period because they exhibited enhanced permeability and retention. Direct evidence was obtained by direct observation of red fluorescence-dyed NBs in tumor tissue using confocal laser scanning microscopy. We have demonstrated the ability to fabricate NBs that can be used for the in vivo contrast-enhanced imaging of tumor tissue and that have potential for drug/gene delivery.
Tinghui Yin; Ping Wang; Rongqin Zheng; Bowen Zheng; Du Cheng; Xinling Zhang; Xintao Shuai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-02-22
Journal Detail:
Title:  International journal of nanomedicine     Volume:  7     ISSN:  1178-2013     ISO Abbreviation:  Int J Nanomedicine     Publication Date:  2012  
Date Detail:
Created Date:  2012-03-06     Completed Date:  2012-06-19     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101263847     Medline TA:  Int J Nanomedicine     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  895-904     Citation Subset:  IM    
Department of Medical Ultrasonic, Third Affiliated Hospital, Guangzhou, People's Republic of China.
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MeSH Terms
Analysis of Variance
Cell Line, Tumor
Cell Survival / drug effects
Contrast Media / chemistry*,  pharmacokinetics
Fluorescent Dyes / chemistry,  pharmacokinetics
Hemolysis / drug effects
Microscopy, Confocal
Nanostructures / chemistry*
Neoplasms / ultrasonography*
Particle Size
Phospholipids / chemistry,  pharmacokinetics
Rats, Sprague-Dawley
Tissue Distribution
Ultrasonography / instrumentation*
Reg. No./Substance:
0/Contrast Media; 0/Fluorescent Dyes; 0/Phospholipids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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